基本信息
- 标准SMILES
O=C([O-])[C@H]1/C(=C/CO)O[C@@H]2CC(=O)N21.[K+]- InChIKey
ABVRVIZBZKUTMK-JSYANWSFSA-M- 分子式
- C8H8KNO5
- 平均分子量
- 237.25 g/mol
- 单同位素质量
- 237.00395384
名称与标识
- 首选名称
- Potassium Clavulanate
- IUPAC
- potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 中文名
- 克拉维酸钾
- 英文名
- Potassium clavulanate
- 分子式
- C8H10KNO5
- 分子量
- 239.27
名称与别名
Potassium clavulanate61177-45-5CLAVULANATE POTASSIUMAmonateBRL 14151KQ42OMW3AT8BRL-14151KCHEBI:85264DTXSID60210067AUGMENTIN COMPONENT CLAVULANATE POTASSIUM4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2alpha,3Z,5alpha))-Clavulanic Acid, Monopotassium Salt
展开更多名称
棒酸棒酸钾克拉维酸钾克拉维酸钾盐克克拉维酸钾克拉维酸钾系列克拉维酸纤维素克拉维酸盐杂质水中克拉维酸钾棒酸+微精纤维素ClavulanatePotassium ClavulanatCLAVULANTE POTASSIUMpotassium calvulanatePotassium clavulanate USP/EP/BPMM 1415brl14151kClavulanate K
Clavulanate, PotassiumPotassium, ClavulanateRefChem:56807DTXCID601325584-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, Monopotassium Salt,(2R-(2alpha,3Z,5alpha))-Monopotassium (2R,5R)-3-((1Z)-2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylateClavulanic Acid Potassium SaltClavulanate (potassium)
数据库标识
- CAS
61177-45-5- PubChem CID
- 23665591
- DTXSID
DTXSID60210067- ChEMBL
CHEMBL1003- ChEBI
CHEBI:85264- UNII
- Q42OMW3AT8
- EC Number
- 262-640-9、689-367-1
- Nikkaji
- J1.462.355H、J86.067K
性质
结构计算性质
- 极性表面积
- 89.9 Ų
- 氢键供体
- 1
- 氢键受体
- 5
- 可旋转键
- 2
- 重原子
- 15
- 形式电荷
- 0
- 复杂度
- 329
物理化学性质
- 熔点
- 1600 C · >1600C (dec)
- 比旋光度
- 55 · +55~+60°
- 储存条件
- 2 · Inert atmosphere,2-8°C
- 溶解度
- Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
- 形态
- Solid
- 颜色
- Light brown to brown
- 主要应用
- agricultureclinicalenvironmentalforensics and toxicologypharmaceutical (small molecule)
- InChI
- InChI=1/C8H9NO5.K.H/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;;/h1,6-7,10H,2-3H2,(H,12,13);;/b4-1-;;/t6-,7-;;/s3
- InChIKey
- ABVRVIZBZKUTMK-JSYANWSFSA-M
- SMILES
- C([C@H]1/C(/O[C@]2([H])CC(=O)N12)=C/CO)(=O)O.[KH] |&1:1,4,r|
- CAS 数据库
- 61177 · 61177-45-5(CAS DataBase Reference)
安全与法规
GHS分类
GHS Classification
Danger
H228 (100%): Flammable solid [Danger Flammable solids]；H252 (74.6%): Self-heating in large quantities; may catch fire [Warning Self-heating substances and mixtures]；H317 (69.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (23.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H334 (69.5%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]；H361 (13.6%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P210, P233, P235, P240, P241, P260, P261, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P333+P317, P337+P317, P342+P316, P362+P364, P370+P378, P403, P405, P407, P410, P413, P420, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 59 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危害信息
Regulatory InformationPotassium clavulanate: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories
Flam. Sol. 1 (100%)；Self-heat. 2 (74.6%)；Skin Sens. 1 (69.5%)；Eye Irrit. 2 (23.7%)；Resp. Sens. 1 (69.5%)；Repr. 2 (13.6%)
Flam. Sol. 2 (100%)；Self-heat. 2 (100%)；Eye Irrit. 2 (100%)
法规信息
Regulatory InformationPotassium clavulanate: Does not have an individual approval but may be used under an appropriate group standard
安全数据
- wgk
- 2
- RTECS号
- RN6802700
- 存储类别
- 4.2 - Pyrophoric and self-heating hazardous materials
- 安全说明
- 8-16-22-36/37-45-43-26
- 海关编码
- 2941900000
- 危险品标志
- F,Xn,Xi
- 危险性类别
- Flam. Sol. 2Resp. Sens. 1Self-heat. 2Skin Sens. 1
- 危险类别码
- 11-42/43-44-36-14
- 危险品运输编号
- UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
化学与工业
药理信息
MeSH Pharmacological ClassificationEndogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES.
用途与制造
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
应用领域
用途属β-内酰胺酶抑制剂
上下游产品信息
上游原料
试剂价格
- HY-A0256A · 5 mg
- 克拉维酸钾Clavulanate potassium — 630元
- HY-A0256A · 10 mg
- 克拉维酸钾Clavulanate potassium — 1098元
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