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乙醚
醚 · 乙醚 · 二乙醚 · 乙基醚 · 无水醚 · 乙氧乙烷 · 麻醉乙醚 · 无水乙醚
标识与物理属性
| CAS No. | 60-29-7 |
|---|---|
| 分子式 | C4H10O |
| 平均分子量 | 74.12 g/mol |
| 单同位素质量 | 74.07316494 g/mol |
| SMILES | CCOCC |
| InChIKey | RTZKZFJDLAIYFH-UHFFFAOYSA-N |
| PubChem CID | 3283 |
| ChEMBL | CHEMBL16264 |
| ChEBI | CHEBI:35702 |
| EC No. | 200-467-2 |
| DTXSID | DTXSID3021720 |
| 中文名 | 乙醚 |
化学与物理性质
| XLogP | 0.9 |
|---|---|
| 极性表面积 | 9.2 |
| 氢键供体 | 0 |
| 氢键受体 | 1 |
| 可旋转键 | 2 |
| 重原子 | 5 |
| 形式电荷 | 0 |
| 复杂度 | 11 |
| LogP（油水分配系数） | log Kow= 0.890.89 (calculated) |
| 气味 | Sweetish, pungent odorEthereal odorPungent odor detectable at 0.33 ppm |
| 味道 | Burning and sweet taste |
| 密度 | 0.714 at 68 °F (USCG, 1999) - Less dense than waterwill float0.7134 at 20 °C/4 °CDensity (at 20 °C): 0.7 g/cm³Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.90.7138 @ 20°C |
| Viscosity | 0.2448 centipoise at 20 °C |
| Color/Form | Colorless, volatile, mobile liquidColorless liquid [Note: A gas above 94 degees F]. |
| 溶解性 | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)Miscible with lower aliphatic alcohols, benzene, chloroform, petroleum ether, fat solvents, many oilssol in concn hydrochloric acidSol in acetonevery sol in ethanolSol in solvent naphtha, benzene, oilsMiscible with most organic solventsIn water, 6.04X10+4 mg/L at 25 °CSoluble in water, miscible with ethanol (96 per cent), with methylene chloride and with fatty oils. It is highly flammable.69 g/L (20 ºC) |
| 闪点 | -49 °F (NTP, 1992)-45 °C-45 °C, -49 °F (CLOSED CUP)-45 °C c.c.-40 °F |
| 沸点 | 94.3 °F at 760 mmHg (NTP, 1992)34.6 °C at 760 mm Hg17.9 °C at 400 mm Hg2.2 °C at 200 mm Hg35 °C94 °F34.5 °C @760 [mm Hg]34.6 °C(lit.) |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes. |
| 熔点 | -177.3 °F (NTP, 1992)-116.3 °C (stable crystals)-123.3 °C (metastable crystals)-116 °C-177 °F-116.2 °C |
| 蒸气密度 | 2.6 (NTP, 1992) - Heavier than airwill sink (Relative to Air)2.55 (Air = 1.0)Relative vapor density (air = 1): 2.62.6 (vs air) |
| 蒸气压 | 28.69 psi ( 55 °C) |
| 折射率 | n20/D 1.3530(lit.) |
| 储存条件 | Store at RT. |
| 形态 | Liquid |
| 颜色 | clearAPHA: ≤10 |
| 比重 | 0.714 (20/4℃)0.712 (25℃) |
| 相对极性 | 2.9 |
| 爆炸极限 | 1.7-36%(V) |
| 热导率 | 0.126 W/(m·K) at 25 ℃ |
| 比热容 | Cp(liquid): 2.33 J/(g·K)Cp(gas): 1.61 J/(g·K), at 25℃ |
| 凝固点 | -116.3℃ |
| Merck | 14,3806 |
| 亨利常数 | 12.50(x 10-4 atmm3/mol at 25 °C) (Signer et al., 1969) |
| 暴露限值 | ACGIH TLV-TWA:1200 mg/m3 (400 ppm)TLV-STEL:1500 mg/m3 (500 ppm)OSHA PEL-TWA:400 ppm (1200 mg/m³) |
| 介电常数 | 4.0(40℃) |
| 稳定性 | Stable, but light-sensitive, sensitive to air. May contain BHT (2,6-di-tert-butyl-4-methylphenol) as a stabilizer. Substances to be avoided include zinc, halogens, halogen-halogen compounds, nonmetals, nonmetallic oxyhalides, strong oxidizing agents, chromyl chloride, turpentine oils, turps substitutes, nitrates, metallic chlorides. Extre |
| 化妆品成分功效 | SOLVENT |
| InChI | 1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3 |
| InChIKey | RTZKZFJDLAIYFH-UHFFFAOYSA-N |
| SMILES | CCOCC |
| LogP（油水分配系数） | 0.890 |
| 表面张力 | 17.153mN/m at 293.15K |
| CAS 数据库 | 60-29-7(CAS DataBase Reference) |
| NIST化学物质信息 | Ethoxy ethane(60-29-7) |
| EPA化学物质信息 | Ethyl ether (60-29-7) |
化学性质
无色易挥发的流动液体，有芳香气味。具有吸湿性，味甜。 溶于乙醇、苯、氯仿及石油，微溶于水。
安全与法规
| GHS 分类 | DangerH224: Extremely flammable liquid and vapor [Danger Flammable liquids]H302: Harmful if swallowed [Warning Acute toxicity, oral]H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposureNarcotic effects]P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P319, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 1.9% (12 of 636) of reports. |
|---|---|
| 法规信息 | Chemical: Ethane, 1,1'-oxybis-List II Chemical: A chemical, other than a List I chemical, specified by regulation that, in addition to legitimate uses, is used in manufacturing a controlled substance in violation of the Act. (21 eCFR 1310.02)Ethane, 1,1'-oxybis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethane, 1,1'-oxybis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 17-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14887Diethyl ether: HSNO Approval: HSR001124 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 运输标签（DOT） | Flammable Liquid |
| 火灾危害 | Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. Decomposes violently when heated. (USCG, 1999)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)· Vapors may form explosive mixtures with air.· Vapors may travel to source of ignition and flash back.· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Vapor explosion hazard indoors, outdoors or in sewers.· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.· Runoff to sewer may create fire or explosion hazard.· Containers may explode when heated.· Many liquids will float on water.Extremely flammable. Vapour/air mixtures are explosive. Risk of fire and explosion on contact with oxidants or incompatible substances. See Chemical Dangers. |
| 火灾可能性 | When shaken under absolutely dry conditions ether can generate enough static electricity to start a fire.A very dangerous fire and explosion hazard when exposed to heat or flame.Only electrical equipment of explosion-proof type (group C classification) is permitted to be operated in ether areas. Ether should not be stored near powerful oxidizers or in areas of high fire hazard. /Ethers/ |
| 健康危害 | Vapor inhalation may cause headache, nausea, vomiting, and loss of consciousness. Contact with eyes will be irritating. Skin contact from clothing wet with the chemical may cause burns. (USCG, 1999)· Inhalation or contact with material may irritate or burn skin and eyes.· Fire may produce irritating, corrosive and/or toxic gases.· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.· Runoff from fire control or dilution water may cause environmental contamination. |
| 危害概述 | Abnormal liver function tests has been reported in patients anesthetized with ethyl ether. Abuse of ether by workers, ether jags, has been reported. [ACGIH] Ethyl ether is in the list of Some volatile substances which may be abused by inhalation published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] An eye and respiratory tract irritant[ICSC] |
| 运输编号与指南（DOT） | 1155 127 |
| 反应性基团 | Ethers |
| 联合国分类 | UN Hazard Class: 3UN Pack Group: I |
| Special Reports | NIOSHNEG and NIOSH Basis for an Occupational Health Standard for Ethyl Ether. Published in Arbete och Halsa 30 (2002) and available at http://www.cdc.gov/niosh/pdfs/93-103a.pdf as of October 31, 2007.European Chemicals BureauIUCLID Dataset, Diethyl Ether (CAS # 60-29-7) p.44 Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of September 24, 2007. |
| RCRA 要求 | U117As stipulated in 40 CFR 261.33, when diethyl ether, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).F003When diethyl ether is a spent solvent, it is classified as a hazardous waste from a nonspecific source (F003), as stated in 40 CFR 261.31, and must be managed according to State and/or Federal hazardous waste regulations. |
| TSCA 要求 | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 1/26/1994Reporting date 3/28/94.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Diethyl ether is included on this list. Effective date 1/26/1994Sunset date 6/30/1998. |
| 消防 | Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Use alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 急救措施 | Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Do NOT induce vomiting. Rinse mouth. Give nothing to drink. Refer for medical attention . |
| 泄漏应急措施 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· All equipment used when handling the product must be grounded.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· A vapor-suppressing foam may be used to reduce vapors.· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.· Use clean, non-sparking tools to collect absorbed material.Large Spill· Dike far ahead of liquid spill for later disposal.· Water spray may reduce vapor, but may not prevent ignition in closed spaces. |
| 急救 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· Wash skin with soap and water.(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Water wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with water. If irritation persists after washing, get medical attention.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
| 安全储存 | Fireproof. Separated from oxidants and other incompatible materials. See Chemical Dangers. Cool. Keep in the dark. Store only if stabilized. Ventilation along the floor. |
| 暴露控制与个人防护 | · Wear positive pressure self-contained breathing apparatus (SCBA).· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.400.0 [ppm] |
| 灭火程序 | Water may be ineffective ... But water should be used to keep fire-exposed containers cool. Use water spray dry chemical, foam, or carbon dioxide.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. |
| 储存条件 | Separate from oxidizing materials. Store in a cool, dry, well-ventilated area. Avoid sunlight.Floors of storage rooms should be conductive ... to ground out any possible static charge of individuals working in the room.Ethers should not be stored near powerful oxidizers or in areas of high fire hazard. They should be kept cool and the containers electrically grounded to avoid sparks. /Ethers/ |
| 清理方法 | Spills and leakage: Absorb with paper. Evaporate completely all spilt surface. Dispose by burning the paper after complete ventilation of vapor.1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Ethyl ether should not be allowed to enter a confined space, such as sewer, because of the possibility of an explosion.A two-well injection withdrawal experiment was conducted at a hazardous waste disposal site near Ottawa, Canada to assess the feasibility of aquifer restoration by means of a purge well network. The six day test involved injecting tracer labeled clean water into one well while withdrawing contaminated water from a well located 5 m away. Samples taken from multilevel sampling points located along flow lines between the two wells were analyzed to determine the concentrations of tracers and of volatile contaminants. Tracer breakthrough data were fitted to an approximate analytic solution to determine average linear velocities and dispersivities. The concentration histories obtained for 3 volatile organic contaminants (including diethyl ether) deviate significantly from that predicted using local equilibrium based transport models. Comparison with results of a one dimensional, kinetics based transport model indicates qualitative agreement between observed transport behavior and that expected for solutes affected by a first order reversible sorption process for which the rate constants are small relative to the groundwater velocity in the induced flow field. |
| 非火灾泄漏应对 | Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024) |
| 处置方法 | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U117, F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Diethyl ether is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. If concentrated waste contains no peroxides, discharge liquid at a controlled rate near a pilot flame. If concentrated waste contains peroxides, perforation of a container of the waste from a safe distance is followed by open burning.A good candidate for liquid injection incineration at a temperture range of 650 to 1,600 °C and a residence time 0.1 to 2 seconds. Also, a good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. Also, a good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.This compound should be susceptible to removal from waste water by air stripping.For more Disposal Methods (Complete) data for DIETHYL ETHER (8 total), please visit the HSDB record page. |
| 泄漏处置 | Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| 体内负荷 | Diethyl ether was detected in 37.5% of 387 samples of normal expired air from 54 carefully selected normal, healthy, non-smoking, urban, adult human volunteers(1). The geometric mean concn of the positive samples was 0.331 ng/L(1). |
| Treatment | There is no antidote for diethyl ether poisoning, thus treatment is symptomatic and supportive. (T36) |
| 相互作用 | The disposition of diflunisal (DF) at 10 mg/kg iv was investigated over 4 hr in bile-exteriorized male rats continuously anaesthetized with ... diethyl ether inhalation (as required) ... and compared to that obtained in conscious rats. 2. Diethyl ether decreased the plasma clearance of DF to about 30% of control values, by inhibition of both glucuronidation and sulfation of DF. ...... Appears to increase the neuromuscular blockade caused by antibiotics such as neomycin, streptomycin, polymyxin, and kanamycin.... In Guinea pigs ... the sleep induced by barbiturates of ether was prolonged by chlordiazepoxide.... Ether ... sleeping times are prolonged by imipramine but considerably less than by phenothiazine neuroleptics.For more Interactions (Complete) data for DIETHYL ETHER (10 total), please visit the HSDB record page. |
| 靶器官 | Eyes, skin, respiratory system, central nervous system |
| 健康影响 | Diethyl ether causes CNS depression. Death due to respiratory depression may result from severe and prolonged exposure. (T36) |
| 生态毒性数值 | LC50 Poecilia reticulata (guppy) 2134 mg/L for 14 dayssemistatic, 22 °CLC50 Pimephales promelas (fathead minnow, age 29 days) 2560 mg/L/96 hrflow-through, 24.8 °C, pH 7.76, dissolved oxygen 7.1 mg/L, hardness 45.1 mg/L CaCO3, alkalinity 41.5 mg/L CaCO3EC50 Pimephales promelas (fathead minnow, age 29 days) 2260 mg/L/96 hrEffect: Affected fish lost schooling behavior and swam in a corkscrew/spiral pattern near the tank surface. They were underreactive to external stimuli, had increased respiration, were darkly colored, and lost equilibrium prior to death.Species: Daphnia magna (Water flea)Conditions: freshwater, static, pH 8.0Concentration: 165 mg/L for 24 hrEffect: behavior, equilibriumFor more Ecotoxicity Values (Complete) data for DIETHYL ETHER (17 total), please visit the HSDB record page. |
| 环境归趋 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 73(SRC), determined from a log Kow of 0.89(2) and a regression-derived equation(3), indicates that diethyl ether is expected to have high mobility in soil(SRC). Volatilization of diethyl ether from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.23X10-3 atm-cu m/mole(4). The potential for volatilization of diethyl ether from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 538 mm Hg(5). Biodegradation of diethyl ether in soil is expected to be a slow process(SRC), based upon its slow biodegradation in an aqueous screening study(6).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 73(SRC), determined from a log Kow of 0.89(2) and a regression-derived equation(3), indicates that diethyl ether is not expected to adsorb to suspended solids and sediment in water(SRC). Diethyl ether is expected to volatilize from water surfaces(3) based on a Henry's Law constant of 1.23X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.1 hours and 3.6 days, respectively(SRC). According to a classification scheme(5), BCFs ranging from 0.9 to 9.1 in carp(6) suggest bioconcentration in aquatic organisms is low(SRC). Biodegradation of diethyl ether in water is expected to be a slow process(SRC), based upon its slow biodegradation in an aqueous screening study(6).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethyl ether, which has an extrapolated vapor pressure of 538 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals(SRC)half-lives for these reactions in air are estimated to be 1.2 and 5.8 days, respectively(3,4). Direct photolysis is not expected to be an important removal process since aliphatic ethers do not absorb light in the environmental spectrum(5). |
| 食品调查数值 | Diethyl ether has been tentatively identified, but not quantified, as a volatile component of raw chicken breast muscle and caecum(1). Diethyl ether was identified as a volatile component of chicken and pork flavor(2). |
| 不良影响 | Neurotoxin - Acute solvent syndromeOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| 暴露途径 | The substance can be absorbed into the body by inhalation of its vapour and by ingestion.inhalation, ingestion, skin and/or eye contactOral (T36)inhalation (T36) |
| 毒性概述 | Diethyl ether inhibits alcohol dehydrogenase. This slows down the metabolism of ethanol and also inhibits the metabolism of other drugs requiring oxidative metabolism. (L1660, A2461) |
| 生态毒性摘录 | /AQUATIC SPECIES/ The study measured the acute toxicity of Ethane, 1,1'-oxybis- to 2-3 month old guppies /(Poecilia reticulate)/ under static-renewal conditions for 14 days. The test substance was tested at several concentrations in a series with a 1.8-factor geometric progression. Stock solutions were prepared using a solvent (acetone or propanol-2) and diluted with standard water (hardness of 25 mg/L as CaCO3). Each test vessel contained approximately 1 L of test solution and eight guppies. Test solutions were renewed daily. Guppies were fed a commercial fish food 0.5 h before each renewal. The temperature and dissolved oxygen concentration during the test were maintained at 22 + or - 1 °C and 5 mg/L, respectively. The guppies were considered to be dead when gill movements ceased and no reaction occurred when fish were touched with a glass bar. LC50 = 2134 mg/L/14 days./AQUATIC SPECIES/ ... Immobility and abnormal behavior (e.g., erratic swimming) were recorded at 24 hours. ... The definitive test was based on a total of 20 daphnids /(Daphnia magna)/ per concentration tested (i.e., 10 daphnids per replicate, in each of 2 replicates) exposed to each test concentration, as well as a control (100% dilution water). Dilution water: Dilution water for culturing was tap water. Dilution water for testing was a chemically and physically defined standardized culture medium ("artificial fresh water"). Measured water chemistry parameters: Parameters determined at the end of the test: pH (target: pH: 8.0 + or - 0.2)dissolved oxygen (target: 2 mg/L)temperature (constant 20 °C in incubator) ... The 24-hour EC50 was ... 165 mg/L/96 hrimmobility. .../AQUATIC SPECIES/ Flow-through exposures /of Ethane, 1,1'-oxybis-/ were made /to Pimephales promelas (fathead minnow)/ with a continuous flow modified mini-diluter. /Alkalinity 41.5 mg/LDO 7.1 mg/LpH 7.76Temperature 24.8 °Cwater hardness 45.1/ ... Observations of fish behavior and toxic signs were made at 2-8, 24, 48, 72 and 96 hours. ... LC50 = 2560 mg/L/96 hrmortality. EC50 = 2260 mg/L/96 hrbehavior. ... Fish exposed to DEE lost schooling behavior and swam in a cork-screw/spiral pattern near the tank surface. They were under reactive to external stimuli, had increased respiration, were darkly colored and lost equilibrium prior to death. .../PLANTS/ Toxicity to terrestrial plants /was studied using/ ...Mimosa pudica, Oxalis stricta, and Marsillia macropus. Inhibition of opening/closing movements /was observed at 330-510 mg/L. ...Effects were reversible after end of exposure within a few hours. |
| 大气标准 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethyl ether is produced, as an intermediate or a final product, by process units covered under this subpart. |
| CERCLA 应报告数量 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| DHS Chemicals of Interest (COI) | Ethyl ether110000Flammable chemical that can be released at a facility. |
| 州饮用水指南 | (FL) FLORIDA 750 ug/l(MN) MINNESOTA 1000 ug/l(NH) NEW HAMPSHIRE 1,400 ug/l |
| F | 10 |
| 水危害等级（WGK） | 1 |
| TSCA 清单状态 | TSCA listed |
| 毒性 | LD50 oral (rat) 1215 mg/kgLC50 inhal (rat) 73,000 ppm (2 h)PEL (OSHA) 400 ppmSTEL (ACGIH) 500 ppm |
| RTECS 号 | KI5775000 |
| 包装类别 | I |
| 危险类别 | 3Acute Tox. 4 OralFlam. Liq. 1STOT SE 3 |
| 储存类别 | 3 - Flammable liquids |
| 安全说明（S） | 9-16-29-33-45-36/37-7 |
| 海关编码 | 2909 11 00 |
| 自燃温度 | 160 °C |
| 危险品标志 | F+,Xn,T,F |
| 危险类别码（R） | 12-19-22-66-67-39/23/24/25-23/24/25-11 |
| 毒害物质数据 | 60-29-7(Hazardous Substances Data) |
| 运输编号（UN） | UN 3271 3/PG II/III (ETHERS, N.O.S.) |
| 立即危及生命和健康浓度 | 1,900 ppm [10% LEL] |
急性毒性
口服- 大鼠 LD50: 1215 毫克/ 公斤; 吸入- 小鼠 LC50: 6500 PPM/ 99分
刺激数据
皮肤- 兔子 360 毫克 轻度; 眼睛- 兔子 100 毫克 中度
职业标准
TWA 1200毫克/立方米; STEL 1500毫克/立方米
爆炸物危险特性
与空气混合可爆
可燃性危险特性
遇明火、高温、氧化剂易燃; 燃烧产生刺激烟雾
储运特性
库房通风低温干燥; 与氧化剂、酸类分开存放
灭火剂
干粉、干砂、干石粉、二氧化碳、泡沫
用途与应用
用途
在有机合成中主要用作溶剂萃取剂和反应介质
用途
常用作分析试剂、溶剂及萃取剂，也用于有机合成
用途
萃取溶剂。按GB 2760-90规定，用作食品加工助剂。
用途
乙醚在有机合成中主要用作溶剂。乙醚在水中的溶解很小，因而可以利用它萃取溶解于水的有机物。乙醚亦能溶解溴、碘、磷、硫、氧化铬、氧化铁、氯化亚锡和氯化汞等无机物。乙醚本身不溶解硝化纤维，但乙醚和乙醇的混合物是硝化纤维的良好溶剂，被应用于无烟火药、棉胶和照相软片的生产。乙醚常用作天然产物的萃取剂或反应介质。但乙醚的挥发性大，且带有麻醉性，作为溶剂使用受到一定的局限。乙醚是最先试用成功的外科麻醉剂。其优点是作用强，安全性大，对心肝及肝脏毒性小，肌肉松驰较完全，不需加用肌肉松驰药。缺点是对粘膜刺激性，麻醉诱导期较长，有燃烧爆炸的危险，以及苏醒中不良反应较多，趋向少用或不用。
用途
用作分析试剂、色谱分析试剂及溶剂
用途
主要用作溶剂、麻醉剂和化学试剂
制备与合成方法
生产方法
1.乙醇-硫酸法 乙醇以浓硫酸为脱水剂，在130-135℃下反应，生成乙醚（推测其反应机理是先生成硫酸乙酯，进而与乙醇作用生成乙醚），再经中和、分馏，得成品。2.从乙烯水合制乙醇副产物回收法 乙醚的主要工业来源是乙烯水合制乙醇时的副产品。乙烯催化水合制乙醇时，当采用固体磷酸催化剂时，约有2%-3%收率的乙醚生成；而在硫酸水合法中，乙醚收率可达8%-10%。根据需要调整反应条件，还可改变乙醇与乙醚的比例或专用于生产乙醚。原料消耗定额：乙醇（95%）1400kg/t、硫酸（98%）45kg/t。
生产方法
由乙醇或乙烯在硫酸作用下脱水后分馏而得。