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乙二胺
乙二胺 · 双酮嗪 · 乙亚胺 · 乙烯二胺 · 乙撑二胺 · 二氨基乙烷 · 2-乙二胺 · 水中乙二胺
标识与物理属性
| CAS No. | 107-15-3 |
|---|---|
| 分子式 | C2H8N2 |
| 平均分子量 | 60.1 g/mol |
| 单同位素质量 | 60.06874826 g/mol |
| SMILES | NCCN |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| PubChem CID | 3301 |
| ChEMBL | CHEMBL816 |
| ChEBI | CHEBI:30347 |
| EC No. | 203-468-6 |
| DTXSID | DTXSID5021881 |
| 中文名 | 乙二胺 |
化学与物理性质
| XLogP | -2 |
|---|---|
| 极性表面积 | 52 |
| 氢键供体 | 2 |
| 氢键受体 | 2 |
| 可旋转键 | 1 |
| 重原子 | 4 |
| 形式电荷 | 0 |
| 复杂度 | 6 |
| 物质类别 | Nitrogen Compounds -> Amines, AliphaticCorrosives |
| 药物 | Pharmaceuticals -> Listed in ZINC15 |
| pH | 11.9 @ 25 °C (25% soln)12.2 (100g/l, H2O, 20℃) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| 农药 | Pesticide -> EPA IRIS |
| LogP（油水分配系数） | log Kow = -2.04 @ pH 13-1.2 |
| 气味 | Ammonia-likeStrong ammoniacal odorammonia-like mild and ammoniacal odor. |
| 食品添加剂 | TRACER -> FDA Substance added to food |
| 密度 | 0.898 at 77 °F (EPA, 1998) - Less dense than waterwill float0.898 @ 25 °C/4 °CSaturated liquid density: 56.650 lb/cu ftliquid heat capacity: 0.694 Btu/lb-Fsaturated vapor pressure: 0.216 lb/sq insaturated vapor density: 0.00228 lb/cu ft (all at 70 °F)Relative density (water = 1): 0.90.911.46 @ 20°C0.899 g/mL at 25 °C (lit.) |
| Viscosity | 0.0154 cP @ 25 °C0.0154 cP at 25 °C |
| Color/Form | Water-white liquidColorless, viscous liquid ... [Note: A solid below 47 degrees F]. |
| 溶解性 | greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)Crystalssublimes without meltingfreely sol in waterpractically insol in alc /Dihydrochloride/Sol in benzene unless insufficiently driedslightly sol in etherSOL IN ALL PROPORTIONS IN ETHYL ALCOHOLVERY SOL IN WATERWater solubility = 1X10+6 mg/lMiscible with water, oxygenated and aromatic solventsethanol: soluble(lit.) |
| 熔点 | 8.5 °C (lit.) |
| 沸点 | 118 °C (lit.) |
| 蒸气密度 | 2.07 (vs air) |
| 蒸气压 | 10 mm Hg ( 20 °C) |
| 折射率 | n20/D 1.4565(lit.) |
| 闪点 | 93 °F |
| 储存条件 | Flammables area |
| pKa（酸度系数） | 10.712(at 0℃) |
| 形态 | Liquid, Fuming In Air |
| 比重 | 0.899 |
| 颜色 | colorless to pale yellow |
| 爆炸极限 | 2-17%(V) |
| 比热容 | Cp(liquid): 2.87 J/(g·K), at 25℃ |
| 敏感性 | Air Sensitive |
| Merck | 14,3795 |
| BRN | 605263 |
| 亨利常数 | 1.69(x 10-9 atmm3/mol) at 25 °C (Westheimer and Ingraham, 1956) |
| 暴露限值 | ACGIH:TLV-TWA 10 ppm (25 mg/m3)OSHA:PEL-TWA 10 ppm (25 mg/m3)NIOSH:REL-TWA 10 ppm |
| 介电常数 | 16.0(18℃) |
| 主要应用 | cleaning productscosmeticsenvironmentalfood and beveragespersonal care |
| InChI | 1S/C2H8N2/c3-1-2-4/h1-4H2 |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| SMILES | NCCN |
| LogP（油水分配系数） | -1.6 at 20℃ |
| CAS 数据库 | 107-15-3(CAS DataBase Reference) |
| NIST化学物质信息 | Ethylenediamine(107-15-3) |
| EPA化学物质信息 | Ethylenediamine (107-15-3) |
化学性质
无色透明的粘稠液体，有氨臭。 能溶于水和乙醇，微溶于乙醚，不溶于苯。
安全与法规
| GHS 分类 | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2078) of reports.H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids] |
|---|---|
| 法规信息 | Chemical: 1,2-EthanediamineHazard Traits - Respiratory ToxicityCommission Regulation No 844/20121,2-Ethanediamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Ethanediamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 02-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15765Substance: Ethylenediamine |
| 其他安全信息 | IMAP assessments - 1,2-Ethanediamine: Environment tier I assessment |
| 运输标签（DOT） | Corrosive Flammable Liquid |
| 火灾危害 | Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur. (EPA, 1998)· Flammable/combustible material.Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 34 °C explosive vapour/air mixtures may be formed. |
| 火灾可能性 | FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.Contact with ... chlorinated organic cmpd may cause fires ... . |
| 健康危害 | Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to ethylenediamine exposuretherefore, safe threshold limits are difficult to set. (EPA, 1998)· May cause toxic effects if inhaled or ingested. |
| 危害概述 | Liquid causes second degree burns after contact for a few minutes[CHRIS] Corrosive to skin[Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p. 85-7] Allergic contact dermatitis in healthcare workers reported after exposure to intravenous aminophylline preparations containing ethylenediamine[Kanerva, p. 1520] Occupational asthma reported in shellac handler and photographer[Malo] Can cause pulmonary edema after an acute inhalation exposure[ICSC] Danger of skin and airway sensitization[MAK] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator[CHEMINFO] |
| 运输编号与指南（DOT） | 1604 132 |
| FDA 要求 | Ethylenediamine is an indirect food additive for use only as a component of adhesives. |
| 反应性基团 | Amines, Phosphines, and Pyridines |
| 欧共体分类 | Symbol: CR: 10-21/22-34-42/43S: (1/2)-23-26-36/37/39-45 |
| 联合国分类 | UN Hazard Class: 8UN Subsidiary Risks: 3UN Pack Group: II |
| 消防 | Wear full protective clothing including gloves and boots. If necessary to enter closed area, wear full-faced gas masks with self-contained breathing apparatus. Use water spray, dry chemical, alcohol foam, or carbon dioxide. Do not use water in case of drum or tank fires. If a leak or spill has not ignited, use water spray to reduce the vapors and dilute spills to nonflammable mixtures. Use water to keep fire-exposed containers cool. (EPA, 1998)Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 急救措施 | Fresh air, rest. Refer immediately for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. |
| 泄漏应急措施 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 急救 | Signs and Symptoms of Acute Ethylenediamine Exposure: Acute exposure to ethylenediamine may result in cough, difficulty in breathing, irritation of the lungs, and pneumonia. Nausea, vomiting, and diarrhea are often seen. Contact with ethylenediamine may result in redness, pain, irritation, and burns.General First Aid:(General first aid procedures) |
| 安全储存 | Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container. |
| 暴露控制与个人防护 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 灭火程序 | Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.Do not use water in case of drum or tank fires. |
| 储存条件 | Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location. |
| 清理方法 | 1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.Overspread /spill with/ sufficient sodium bisulfate and sprinkle water. |
| 非火灾泄漏应对 | Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: |
| 处置方法 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Catalytic /destruction/ of waste gases from ethylenediamine production is described.Removal of ethylenediamine from wastewater using ion exchange is described. |
| 泄漏处置 | Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Collect the spilled substance into containers. The container should be made of the same material as the original container. |
| 相互作用 | Ethylenediamine (EDA) (31.6-1000 mg/kg, ip) inhibited the convulsive effects of pentylenetetrazol (100 mg/kg, ip) in mice. EDA (100-1000 mg/kg, ip) incr the convulsion threshold to the iv infusion of 3 convulsants in the order pentylenetetrazol > bicuculline > strychnine.A 37-yr-old pt sensitized to ethylenediamine by topical use of a steroid cream for scaly rash, developed an itchy morbilliform rash affecting the whole body following piperazine citrate therapy for threadworms. |
| 靶器官 | Skin, respiratory system, liver, kidneys |
| 生态毒性数值 | LC50 Pimephales promelas (fathead minnow) 115.7 mg/l/96 hr @ 22 °C (95% confidence limit 98.6-131.6 mg/l) /Static bioassay/TLM: ORYZIAS LATIPES 1000 MG/L/24 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 52 mg/l /Conditions of bioassay not specified/Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 0.85 mg/l /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for ETHYLENEDIAMINE (9 total), please visit the HSDB record page. |
| 环境归趋 | TERRESTRIAL FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to have slight mobility in soil(SRC). Volatilization of ethylenediamine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-9 atm-cu m/mole(3). The potential for volatilization of ethylenediamine from dry soil surfaces may exist based upon a vapor pressure of 12.1 mm Hg(4). However, adsorption to soil may attenuate volatilization(SRC). Based on screening studies(5-7), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in soil are available. Ethylenediamine may also form stable complexes with metal ions(8) in soil, but again, experimental data are lacking(SRC).AQUATIC FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole(4). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonatedthe dissociated form will not volatilize. According to a classification scheme(5), an estimated BCF of less than 1(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Based on screening studies(8-10), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in water are available. Complexation of ethylenediamine with transition metals(11) in the water or reaction with humic materials(12) is possible(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine, which has a vapor pressure of 12.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor. Vapor-phase ethylenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.3x10-11 cu cm/molecule-sec at 25 °C(3) using a structure estimation method(3). As ethylenediamine is miscible in water(4), washout by rain will also be an important removal process(SRC). |
| 食品调查数值 | ... Amines from decomposing fish ... /Amines/ |
| 不良影响 | Dermatotoxin - Skin burns. |
| 暴露途径 | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Signs and Symptoms | Cough. Sore throat. Shortness of breath. Burning sensation. Wheezing. Shortness of breath.Redness. Pain. Burning sensation. Skin burns.Redness. Pain. Blurred vision. Severe burns.Burns in mouth and throat. Sore throat. Burning sensation. Abdominal pain. Shock or collapse.irritation nose, respiratory systemsensitization dermatitisasthmaliver, kidney damage |
| EPA IRIS Information | Ethylene diamine |
| Medical Surveillance | ... A complete history and physical exam /is required/ ... to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of asthma, allergies, or unknown sensitization to ethylenediamine would be expected to be at incr risk from exposure. Exam of the resp system, liver, and kidneys should be stressed. The skin should be examined for evidence of chronic disorders. ... Should be repeated on an annual basis. |
| Soil Adsorption/Mobility | Ethylenediamine has two primary amine groups and at the pH range found in most soils it is expected to be partially protonated given a pKa1 of 10.7 and a pKa2 of 7.6(1). An average Koc of 4766 (range=2071 to 6160) was measured for ethylenediamine in six different soilsfive were from the vadose zone and one from an aquifer (saturated zone)(2). pH values ranged from 6.0 to 9.6 and the fraction of organic carbon from 0.0024 to 0.0391 for this group of soils. Soils with increased cation exchange capacity and organic content had greater affinity for ethylenediamine(2). |
| TSCA Test Submissions | Ethylenediamine (CAS # 107-15-3) was evaluated for acute oral toxicity in groups of Fischer 344 rats (5/sex/group) administered single oral doses of 200, 400, 800, 1200, and 1800 mg/kg bodyweight as a monohydrochloride or dichlorohydride salt in water. Mortality was attributed to treatment at doses of 1800 mg/kg (9/10) and 1200 mg/kg (2/10)An LD50 was not calculated. Clinical signs observed in the 1200 mg/kg group included emaciation, bluish extremities and diarrhea. Upon necropsy, no gross pathology was observed. |
| 大气标准 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylenediamine is produced, as an intermediate or a final product, by process units covered under this subpart. |
| CERCLA 应报告数量 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ethylenediamine is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10,000 lbs.Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 清洁水法要求 | Ethylenediamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| DHS Chemicals of Interest (COI) | Ethylenediamine120000Toxic chemical that can be released at a facility. |
| 州饮用水指南 | (FL) FLORIDA 10,000 ug/l |
| F | 10-34 |
| 水危害等级（WGK） | 2 |
| TSCA 清单状态 | TSCA listed |
| 毒性 | LD50 orally in rats: 1.16 g/kg (Smyth) |
| RTECS 号 | KH8575000 |
| 包装类别 | II |
| 危险类别 | 8Acute Tox. 3 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Chronic 3Eye Dam. 1Flam. Liq. 3Resp. Sens. 1BSkin Corr. 1BSkin Sens. 1B |
| 储存类别 | 3 - Flammable liquids |
| 安全说明（S） | 23-26-36/37/39-45 |
| 海关编码 | 29212110 |
| 自燃温度 | 716 °F |
| 危险品标志 | C |
| 危险类别码（R） | 10-21/22-34-42/43 |
| 毒害物质数据 | 107-15-3(Hazardous Substances Data) |
| 职业暴露等级（OEB） | A |
| 职业暴露限值（OEL） | TWA: 10 ppm (25 mg/m3) |
| 运输编号（UN） | UN 1604 |
| 立即危及生命和健康浓度 | 1,000 ppm |
急性毒性
口服- 大鼠 LD50: 500 毫克/ 公斤; 吸入- 小鼠 LC50: 300 毫克/ 立方米
刺激数据
皮肤- 兔子 10 毫克/ 24小时 重度; 眼睛- 兔子 0.75 毫克/ 24小时 重度
职业标准
TWA 25毫克/ 立方米; STEL 35 毫克/ 立方米
爆炸物危险特性
与空气混合可爆
可燃性危险特性
遇明火、高温、氧化剂较易燃; 燃烧产生有毒氮氧化物烟雾
储运特性
库房通风低温干燥; 与氧化剂、酸类分开存放
灭火剂
干粉、二氧化碳、泡沫、1211灭火剂
用途与应用
用途
用于医药、农药、染料、塑料、橡胶等工业
用途
乙二胺又名1，2-二氨基乙烷，是杀菌剂代森铵、代森锌、代森锰锌的中间体，也是杀虫剂吡虫啉的原料。
用途
乙二胺是重要的化工原料，广泛用以制造有机化合物、高分子化合物、药物等，用于生产农药杀菌剂（代森锌、代森铵）、杀虫剂、除草剂、染料、染料固色剂、合成乳化剂、破乳剂、纤维表面活性剂、水质稳定剂、除垢剂、电镀光亮剂、纸的湿润强化剂、粘接剂、金属螯合剂EDTA、环氧树脂固化剂、橡胶硫化促进剂、酸性气体的净化剂、照相显影添加剂、超高压润滑油的稳定剂、焊接助熔剂、氨基树脂、乙二胺脲醛树脂等等。还用于有机溶剂和化学分析试剂，以及用于铍、铈、镧、镁、镍、钍、铀等金属的鉴定，锑、鉍、镉、钴、铜、汞、镍、银和铀的测定等。
用途
用于治疗牛皮癣，对恶性淋巴瘤、头颈部肿瘤、软组织肉瘤也有一定的缓解作用
用途
用作分析试剂、有机溶剂、抗冻剂和乳化剂
用途
用作分析试剂、环氧树脂固化剂，也用于有机合成及制药工业
制备与合成方法
生产方法
1.二氯乙烷氨化法将1,2-二氯乙烷和液氨送入反应器中，在120-180℃温度和1.98-2.47MPa压力下，进行热氨解反应，将反应液蒸发一部分水分和过量的氨、然后送入中和器，用30%液碱中和，再经浓缩、脱盐、粗馏得粗乙二胺、粗三胺和多胺混合物，最后再将粗乙二胺在常压下精馏得乙二胺成品，其含量为70%，再加压精馏可得90%的成品。反应过程还副产二乙撑三胺，继续反应还生成三乙撑四胺，四乙撑五胺等多乙撑多胺。2.乙醇胺氨化法将乙醇胺、钴催化剂和水加入反应器，然后往其中通入氨和氢，在20MPa和170-230℃下进行反应，5-10h后，可制得乙二胺，其转化率达69%。反应过程的副反应还生成二乙撑三胺、哌嗪、氨乙基哌嗪、羟乙基哌嗪等。3.环氧乙烷氨化法。此外，从生产医药产品六水哌嗪的母液中，也可分馏得到乙二胺。
生产方法
其制备方法有二氯乙烷法和乙醇胺法。(1)二氯乙烷法由二氯乙烷与氨直接合成，在钼钛不锈钢反应管道内进行，反应温度控制在160～190℃，压力为2.452 MPa，反应时间1.5min，反应后的合成液经蒸发一部分水分和过量氨进人中和器，用30％碱液中和，然后经浓缩、脱盐、粗馏得粗乙二胺、粗三胺、粗多胺等混合物，最后再将粗乙二胺在常压精馏得乙二胺成品，其含量70％，在加压下蒸馏可得90％纯度的产品。反应方程式如图：$SClCH2CH2Cl+2NH4OH→HCl·H2NCH2CH2NH2·HCl+2H2O[2NaOH]→NH2CH2CH2NH2+2Nacl(2)乙醇胺法将乙醇胺、氨和循环物料蒸发成气相混合物通入固定床反应器，反应在氢气流中进行，反应温度为300℃，压力为25 MPa，反应生成物部分冷凝后分出气相的氨和氢气，经压缩返回反应器，液相反应物经脱氨后脱水塔后进入精馏塔，从塔顶蒸出乙二胺和哌嗪，进一步分解得乙二胺成品。NH2CH2CH2OH+NH3→NH2CH2CH2NH2+H2O