盐酸羟胺

Hydroxyamine hydrochloride

HCID 443297CAS 5470-11-1

基本信息

标准SMILES
Cl.NO
InChIKey
WTDHULULXKLSOZ-UHFFFAOYSA-N
分子式
ClH.H3NO
平均分子量
69.49 g/mol

概述

Hydroxylamine hydrochloride appears as colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2. (NTP, 1992)

名称与标识

首选名称
Hydroxyamine hydrochloride
IUPAC
hydroxylamine;hydrochloride
中文名
盐酸羟胺
英文名
Hydroxylamine hydrochloride
分子式
NH2OH·HCl
分子量
69.49

名称与别名

Hydroxylamine hydrochloride5470-11-1Hydroxylammonium chlorideOxammonium hydrochlorideHydroxyamine hydrochlorideHydroxylamine chloride (1:1)NSC-262505X4ZA62Z4QHYDROXYLAMINE CHLOROHYDRATERefChem:5895226-798-2DTXCID501476239
展开更多名称
羟胺酸盐酸胲氯化羟胺盐酸羟胺氢氯羟胺氯化羟铵胲鹽酸鹽氯化羥胺羟胺盐酸盐酸羧胺HYDROXYLAMINE HCLHYDROXYLAMINE HYDROCHLORIDhydroxyaminehydrochlorideHydroxylamine hydrocOXAMMONIUM HCLHA HCLOxammionium
DTXSID7025425Hydroxyammonium chlorideHydroxylamine chlorideHYDROXYLAMINE, HYDROCHLORIDEhydroxylamine;hydrochlorideMFCD00051089hydroxyl amine hydrochlorideHydroxyamine (hydrochloride)

数据库标识

CAS
5470-11-1
PubChem CID
443297
ChEMBL
CHEMBL542448
ChEBI
CHEBI:5807
UNII
5X4ZA62Z4Q
EC Number
226-798-2

性质

结构计算性质

极性表面积
46.3 Ų
氢键供体
3
氢键受体
2
可旋转键
0
重原子
3

实验与物化性质

Chemical ClassesNitrogen Compounds -> Hydroxylamines
Density · 3 条

1.67 at 63 °F (NTP, 1992) - Denser than water; will sink

1.7 g/cm³

1.6717 @25 °C

Solubility · 2 条

greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)

Solubility in water, g/100ml at 25 °C: 94 (freely soluble)

Boiling PointDecomposes (NTP, 1992)
Melting Point · 3 条

304 °F (Decomposes) (NTP, 1992)

304 °F (decomposes)

154 °C

Physical Description · 3 条

Hydroxylamine hydrochloride appears as colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2. (NTP, 1992)

Colorless to off-white crystals that are hygroscopic and water soluble; [CAMEO]

COLOURLESS HYGROSCOPIC CRYSTALS.

物理化学性质

熔点
155 · 155-157 °C (dec.)(lit.)
密度
1.67 g/mL · 1.67 g/mL at 25 °C(lit.)
堆积密度
900 kg/m3 · 900kg/m3
蒸气压
0.054 Pa · 0.054 Pa (50 °C)
储存条件
15 °C · Store at +15°C to +25°C.
溶解度
470 g/l · 470g/l

化学性质

白色针状结晶,易潮解。 溶于水、乙醇和甘油,不溶于乙醚。

安全与法规

GHS分类

GHS Classification · 6 条

Warning

H290: May be corrosive to metals [Warning Corrosive to Metals]

P203, P234, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P390, P391, P405, P406, and P501 (click each P-code to see the statement)

Warning

H290 (99.8%): May be corrosive to metals [Warning Corrosive to Metals]

P203, P234, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P390, P391, P405, P406, and P501 (click each P-code to see the statement)

危害信息

Regulatory Information · 3 条

Chemical: Hydroxylamine, hydrochloride

Status: Active Update: 18-11-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/24099

Hydroxylammonium chloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Hydroxylamine and its salts: Human health tier II assessment
DOT LabelCorrosive Poison
Fire Hazards · 2 条

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion as a result of decomposition when heated.

Health Hazards · 1 条

SYMPTOMS: Symptoms of exposure to this chemical include eye, skin and mucous membrane irritation; burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, vomiting and methemoglobinemia. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi; chemical pneumonitis and pulmonary edema.

Hazards Summary · 1 条

A powerful reducing agent and a strong irritant of the skin and eyes; Can cause methemoglobinemia; Inhalation of high concentrations can induce toxic pneumonitis; [CAMEO] Negligible evaporation at room temperature; Harmful if dispersed particles are inhaled; A skin sensitizer; [ICSC] Causes skin burns; [MSDSonline] See Hydroxylamine.

安全与防护

Fire Fighting · 2 条

Fires involving this material can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

In case of fire in the surroundings, use appropriate extinguishing media.

First Aid Measures · 4 条

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

First Aid · 1 条

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Safe StorageDry. Cool. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Nonfire Spill Response · 1 条

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Spillage Disposal · 1 条

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered non-metallic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

毒理信息

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
Signs and Symptoms · 4 条

Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Unconsciousness.

MAY BE ABSORBED! Redness. Pain. Further see Inhalation.

Redness. Pain.

See Inhalation.

ICSC Environmental DataThe substance is very toxic to aquatic organisms.

安全数据

F
21
wgk
3
tsca
TSCA listed
毒性
LD50 orally in mice: 408 mg/kg (Riemann)
RTECS号
NC3675000
包装类别
III

化学与工业

用途与制造

Uses · 2 条

Hydroxylamine is used in organic synthesis; in photographic developers; in the production of rubber, plastics, and steel; and in the separation of uranium and plutonium; [Ullmann]

Steel Producing [Category: Industry]

General Manufacturing InformationHydroxylamine, hydrochloride (1:1): ACTIVE
应用领域 · 4 条

简介盐酸羟胺呈无色单斜结晶状,易溶于水,溶于乙醇、甘油,不溶于乙醚。吸湿性强,受潮后逐渐分解。加热至151°C以上亦分解。

用途盐酸羟胺可用作合成抗癌药(羟基脲)、磺胺药(新诺明)和农药(灭多威)的原料。

用途羟胺盐酸盐是氨基甲酸肟酯类杀虫剂如灭多威、涕灭威、硫双灭多威等的中间体,也是制备2,6-二氯苯腈、邻氯苯肟等的原料。有机合成工业中作为还原剂,制备肟类,还用于生产医药、染料,用于彩色照相和影片的洗印。在合成橡胶工业中用作不着色的短期中止剂,分析化学中用于醛类和酮类有机化合物的检验及磺酸的微量分析,电分析中用作去极剂,在医药方面用于生产新诺明、达那唑、炔雌醇、炔诺酮、甲基睾丸素、羟基脲、利眠宁等。

用途盐酸羟胺可用作还原剂和显像剂,用于彩色照相和影片的洗印。有机合成工业中作还原剂,制备肟类及抗癌药和磺胺药。在医药方面还用于生产新诺明、达那唑、炔雌醇、炔诺酮、甲基睾丸素、羟基脲、利眠宁等。在合成橡胶工业中,用作不着色的短期中止剂。分析化学中,用于醛类和酮类有机化合物的检验及磺酸的微量分析,钢铁中镁成分测定,电分析中用作去极剂。还用于生产染料。

制备方法 · 4 条

制备把丁酮肟、盐酸投入带精馏塔的高压釜,密闭系统,升温到一定的温度和压力,回收反应生成的丁酮,余料降温结晶抽滤得盐酸羟胺。2

生产方法1.亚硝酸钠合成法(肟化法)将水加入反应釜,搅拌下加入亚硝酸钠,分次加入焦亚硫酸钠,然后用硫酸酸化。将酸化后的物料送入水解釜,加入丙酮,再用液碱中和,将中和液蒸馏,得丙酮肟。将丙酮肟和盐酸加入成盐釜中反应,生成盐酸羟胺和丙酮。丙酮回收使用;盐酸羟胺经浓缩、冷却结晶、离心分离、干燥,即得成品。原料消耗定额:亚硝酸钠(95%)1970kg/t、焦亚硫酸钠(以SO2计64%)5418kg/t、丙酮(98%)1175kg/t。2.硝基甲烷法硝基甲烷与盐酸、水作用以制得盐酸羟胺。按HGB3044-76,盐酸羟胺产品为白色结晶,二级品含量≥98.5,三级品含量≥97%。原料消耗定额:硝基甲烷1200kg/t、盐酸(30%)1500kg/t。

生产方法其制备方法是将水加入反应釜,搅拌下加入亚硝酸钠,分次加入焦亚硫酸钠,然后用硫酸酸化。将酸化后的物料送入水解釜,加入丙酮,再用液碱中和,将中和液蒸馏,得丙酮肟。将丙酮肟和盐酸加入成盐釜中反应,生成盐酸羟胺和丙酮。丙酮回收使用;盐酸羟胺经浓缩、冷却结晶、离心分离、干燥,即得成品。反应方程式:NaNO2[NaHSO3]→[H2SO4]HON(SO3Na)2[(CH3)2CH]→HON=C(CH3)2[HCl]→NH2OH·HCl另一种生产方法是硝基甲烷法。由硝基甲烷与盐酸反应制得盐酸羟胺。反应方程式:CH3NO2[HCl]→[H2O]NH2OH·HCl

生产方法肟化法首先在合成釜中加入一定量的水,在搅拌下加入一定量的亚硝酸钠,分次加入一定量的焦亚硫酸钠,然后用硫酸酸化。酸化后的料液送入水解釜,加入一定量的丙酮,然后加入液碱中和。把中和液吸入蒸馏釜,蒸馏出丙酮肟。将丙酮肟和一定配比的盐酸加入成盐浓缩釜中进行反应,生成盐酸羟胺和丙酮。丙酮回收供水解用。盐酸羟胺经浓缩、冷却结晶、离心分离、干燥,制得盐酸羟胺成品。其Na2S2O5+H2O→2NaHSO3NaNO2+2NaHS3→HON(SO3Na)2+NaOHNaOH+H2SO4→NaHSO4+H2OHON(SO3Na)2+(CH3)2CO+H2O→(CH3)2CNOH+2NaHSO4(CH3)2CNOH+HCl+H2O→NH2OH·HCl+(CH3)2CO

试剂价格

A15398 · 500g
盐酸羟胺, 99% Hydroxylamine hydrochloride, 99% — 977元
036416 · 500g
盐酸羟胺, ACS, 96+%Hydroxylamine hydrochloride, ACS, 96+%, Thermo Scientific Chemicals — 507元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东隆汇化工有限公司531-88613858 15562516958 · [email protected]

相关反应

7,871 条

关联笔记

加载中…