氧化苯胂

Phenylarsine Oxide

HCID 4778CAS 637-03-6

基本信息

标准SMILES
O=[As]c1ccccc1
InChIKey
BQVCCPGCDUSGOE-UHFFFAOYSA-N
分子式
C6H5AsO
平均分子量
168.02 g/mol
单同位素质量
167.95563628

概述

Phenylarsine oxide is an arsine oxide derived from phenylarsine. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent and an apoptosis inducer.

名称与标识

首选名称
Phenylarsine Oxide
IUPAC
arsorosobenzene
中文名
氧化苯胂
英文名
Phenylarsine oxide
分子式
C6H5AsO
分子量
168.02

名称与别名

phenylarsine oxide637-03-6OxophenylarsinearsorosobenzeneArzenePhenylarsenoxideArsenosobenzeneARSINE, OXOPHENYL-Phenyl arsine oxideFenylarsinoxidPhAsODTXSID5042249
展开更多名称
苯砷氧苯胂化氧氧化苯砷氧化苯胂苯基氧化砷苯砷酰氧化物等离子体胺氧化酶氧化苯砷,97%氧化苯胂,98%等离子体胺氧化酶/PAOPolyalphaolefinsPAOPoly α-olefinsarsenoso-benzenoxophenyl-arsin
0HUR2WY345NSC-42470DTXCID3022249CHEBI:75253RefChem:861713211-275-32-(Hydroxypropyl)phenylarsinic acidBenzene, arsenoso-

数据库标识

CAS
637-03-6
PubChem CID
4778
DTXSID
DTXSID5042249
ChEMBL
CHEMBL477683
ChEBI
CHEBI:75253
UNII
0HUR2WY345
EC Number
211-275-3
Nikkaji
J6.913B

性质

结构计算性质

极性表面积
17.1 Ų
氢键供体
0
氢键受体
1
可旋转键
0
重原子
8

实验与物化性质

Chemical ClassesMetals -> Arsenic Compounds, Organic
Physical DescriptionCrystals with a melting point of 144-146 degrees C; [Merck Index]

物理化学性质

熔点
145 · 145-148 °C
储存条件
Poison room
溶解度
50 mg/mL · DMSO: 50 mg/mL
形态
powder
颜色
white to yellow
生物来源
synthetic (organic)

化学性质

结晶。熔点144-146℃(119-120℃)。易溶于氯仿、热乙醇、热苯,微溶于乙醇,不溶于水和乙醚。

安全与法规

GHS分类

GHS Classification · 4 条

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 2 条

Chemical: Arsine, oxophenyl-

Restricted substance: Phenylarsine oxide

Hazards Summary · 1 条

Acute or chronic arsenic poisoning may result from ingestion or inhalation of a sufficient dose; [MSDSonline] Not found in any pesticide products; [NPIRS] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles]

Hazard Classes and CategoriesAcute Tox. 3 (100%)

安全与防护

Exposure Control and Personal Protection · 1 条

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

Permissible Exposure Limit (PEL)0.5 [mg/m3], as As

安全数据

wgk
3
tsca
TSCA listed
毒性
LD50 ipr-mus: 1930 mg/kg JPETAB 74,210,42
RTECS号
CH8100000
包装类别
III
危险等级
6.1

化学与工业

药理信息

MeSH Pharmacological Classification · 2 条

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

用途与制造

UsesInhibits protein-tyrosine-phosphatase. [ChemIDplus] Used in veterinarian medicine as a poultry coccidiostat; [6949, Merck Index]
General Manufacturing InformationArsine, oxophenyl-: ACTIVE

应用领域

用途用于有机合成。该品剧毒,用作杀虫剂。

制备方法

生产方法将苯砷酸、甲醇、浓盐酸按重量比1:5:2混合,加入少许碘化钾,然后通入二氧化硫至饱和。将反应生成的油状苯二氯砷用氢氧化钠溶液溶解,再用盐酸中和,使苯砷氧沉淀出来。

上下游产品信息

试剂价格

P0140 · 1G
氧化苯胂Phenylarsine Oxide — 270元
P0140 · 5G
氧化苯砷Phenylarsine Oxide — 970元

供应商50 家

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海仲因实业有限公司2537653158 16621191650 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

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