维吉尼亚霉素M1

Virginiamycin M1

HCID 5459319CAS 21411-53-0

基本信息

标准SMILES: CC1=C\[C@@H](O)CC(=O)Cc2nc(co2)C(=O)N2CCC=C2C(=O)O[C@H](C(C)C)[C@H](C)/C=C/C(=O)NC\C=C\1
InChIKey: DAIKHDNSXMZDCU-FQTGFAPKSA-N
分子式: C28H35N3O7
平均分子量: 525.6 g/mol
单同位素质量: 525.24750046

概述

Pristinamycin IIA is a macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus. It has a role as a Mycoplasma genitalium metabolite and an antibacterial drug. It is a secondary carboxamide, a tertiary carboxamide, a pyrroline, a lactam, a macrolide antibiotic, a macrolide, a secondary alcohol, a cyclic ketone, a member of 1,3-oxazoles and an enamide.

名称与标识

首选名称: Virginiamycin M1
IUPAC: (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone
中文名: 维吉尼亚霉素M1
英文名: VIRGINIAMYCIN M1
分子式: C28H35N3O7
分子量: 525.59

名称与别名

virginiamycin m1Streptogramin AMikamycin APristinamycin IIAVirginiamycin Factor M1VERNAMYCIN AStaphylomycin M1Antibiotic PA 114A121411-53-0Antibiotic pa 114a8W4UOL59AZPA-114A

展开更多名称

蛎灰菌素春霉素 A蛎灰菌素A奥斯立星A维吉霉素M1普那霉素ⅡA始霉素 ⅡA普利霉素IIA普那霉素IIA维吉尼霉素M1C11299PA 114AFactor MNSC 87432NSC 244426STAPHYLOMYCIN

NSC-87432NSC-244426RP-12536CHEBI:99978,9,14,15,24,25-Hexahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetroneDTXSID30873800NSC87432Staphylomycin M

数据库标识

CAS: 21411-53-0
PubChem CID: 5459319
DTXSID: DTXSID30873800
ChEMBL: CHEMBL1236670
ChEBI: CHEBI:9997
UNII: 8W4UOL59AZ
EC Number: 244-376-6

性质

结构计算性质

XLogP: 2.5
极性表面积: 139 Å²
氢键供体: 2
氢键受体: 8
可旋转键: 1
重原子: 38
形式电荷: 0
复杂度: 1,030

实验与物化性质

DrugsPharmaceuticals -> Antibiotics

SolubilityPoorly soluble in water

物理化学性质

熔点: 165 · 165-167℃
比旋光度: 20 · D20 -218° ( c = 0.34 in ethanol)
沸点: 825.2 · 825.2±65.0 °C(Predicted)
密度: 1.26 · 1.26±0.1 g/cm3(Predicted)
储存条件: 2 · 2-8°C
溶解度: 10 mg/mL · chloroform/methanol: soluble10mg/mL
酸度系数(pKa): 13.18 · 13.18±0.70(Predicted)
形态: powder
颜色: yellow to tan
稳定性: Light Sensitive
InChIKey: DAIKHDNSXMZDCU-QHKJSJJMSA-N
SMILES: CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c3coc(CC(=O)C[C@H](O)C=C(C)C=CCNC(=O)C=C[C@H]1C)n3

安全与法规

安全数据

wgk: 3
存储类别: 11 - Combustible Solids
海关编码: 29419090

化学与工业

药理信息

Mechanism of Action · 1 条

Virginiamycin M1 is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Virginiamycin M1 has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus.

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

试剂价格

HY-N6686 · 1 mg: 维吉尼亚霉素M1Virginiamycin M1 — 920元
HY-N6686 · 5mg: 维吉尼亚霉素M1Virginiamycin M1 — 2022元

供应商50 家

北京华美互利生物化工010-56205725 · [email protected]

阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

关联笔记

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