尿苷5'-三磷酸酯

Uridine 5'-triphosphate

HCID 6133CAS 63-39-8

基本信息

标准SMILES: O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1
InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N
分子式: C9H15N2O15P3
平均分子量: 484.14 g/mol
单同位素质量: 483.96852767

概述

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a uridine 5'-phosphate and a pyrimidine ribonucleoside 5'-triphosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

名称与标识

首选名称: Uridine 5'-triphosphate
IUPAC: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
中文名: 尿苷5'-三磷酸酯
英文名: UTP
分子式: C9H15N2O15P3
分子量: 484.14

名称与别名

uridine 5'-triphosphateuridine triphosphate63-39-8UteplexDTXSID0041147INS-316UT0S826Z60[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateMagnesium UTPUTP, MagnesiumTriphosphate, UridineMg UTP

展开更多名称

尿苷三磷酸二喹唑醇杂质B地夸磷索杂质B二喹福索杂质B尿苷-5'-三磷酸尿苷5'-三磷酸酯尿苷-5-三磷酸钠盐UTP【尿苷三磷酸】尿苷5'-三磷酸锂盐三磷酸尿酐二钠(UTP)UTP TRISODIUM SALTURIDINE-5'-TRIPHOSPHATE TRISODIUM SALTUTP-NAUTP SodiumpppU5’-utpUTP, 3NA

Magnesium Uridine TriphosphateTriphosphate, Magnesium Uridine(((2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphateRefChem:901473DTXCID8021147(((((((2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonic acid200-558-7Uridine 5'-(tetrahydrogen triphosphate)

数据库标识

CAS: 63-39-8
PubChem CID: 6133
DTXSID: DTXSID0041147
ChEMBL: CHEMBL336296
ChEBI: CHEBI:15713
UNII: UT0S826Z60
EC Number: 200-558-7
Nikkaji: J4.827E

性质

结构计算性质

XLogP: -5.8
极性表面积: 259 Å²
氢键供体: 7
氢键受体: 15
可旋转键: 8
重原子: 29
形式电荷: 0
复杂度: 839

实验与物化性质

Chemical ClassesBiological Agents -> Nucleic Acids and Derivatives

DrugsPharmaceuticals -> Listed in ZINC15

Physical DescriptionSolid

Collision Cross Section · 3 条

187 Å² [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

178.55 Å² [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]

188.5 Å² [M+Na]+

物理化学性质

密度: 2.106 · 2.106±0.06 g/cm3(Predicted)
闪点: 113 °C · 113 °C
储存条件: 2 · Sealed in dry,2-8°C
溶解度: Easily soluble (water)
酸度系数(pKa): 1 · pK1:7.58 (25°C)
形态: liquid
颜色: colorless
PH值: 7 · 7.0 ± 0.1
生物来源: yeast (Candida Utilis)
水溶解性: 150 mg/mL · Water : ≥ 150 mg/mL (309.83 mM)
InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N
SMILES: C(OP(=O)(O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O
CAS 数据库: 63 · 63-39-8(CAS DataBase Reference)
EPA化学物质信息: 5 · Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)

安全与法规

危害信息

Regulatory InformationUridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryA skin and strong eye irritant; Harmful by ingestion; [Ark Pharm MSDS]

安全数据

wgk: 1
安全说明: 22-26-36
危险品标志: Xn
危险类别码: 20/21/22-68/20/21/22

化学与工业

药理信息

Cellular LocationsCytoplasm

Metabolite PathwaysAmikacin Action Pathway

用途与制造

Uses · 2 条

Pyrimidine analog of adenosine triphosphate (ATP); Used to treat cystic fibrosis; [Merck Index]

Use (kg; approx.) in Germany (2009): >10

上下游产品信息

上游原料

下游产品

尿苷5-单磷酸鸟苷三磷酸尿苷5'-二磷酸酯尿嘧啶核苷-5′-二磷酸-N-乙酰氨基半乳糖二钠盐

试剂价格

HY-107372 · 5 mg: 尿苷5'-三磷酸酯Uridine triphosphate — 375元
HY-107372 · 10mg: 尿苷5'-三磷酸酯Uridine triphosphate — 600元

供应商50 家

北京华美互利生物化工010-56205725 · [email protected]

杭州启因生物科技有限责任公司17368759907 · [email protected]

广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

Zhejiang Hengkang Pharmaceutical Co., Ltd.+86-576-83372028 +86-18868723926 · [email protected]

上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]

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