羟乙酸甲酯

Methyl Glycolate

HCID 66774CAS 96-35-5
子结构检索查找相似结构

基本信息

标准SMILES
COC(=O)CO
InChIKey
GSJFXBNYJCXDGI-UHFFFAOYSA-N
分子式
C3H6O3
平均分子量
90.08 g/mol
单同位素质量
90.03169405

概述

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Methyl Glycolate...

名称与标识

首选名称
Methyl Glycolate
IUPAC
methyl 2-hydroxyacetate
中文名
羟乙酸甲酯
英文名
Methyl glycolate
分子式
C3H6O3
分子量
90.08

名称与别名

Methyl glycolate96-35-5Methyl hydroxyacetateAcetic acid, hydroxy-, methyl esterGlycolic acid, methyl esterAcetic acid, 2-hydroxy-, methyl ester7G7R729EJ0NSC-27786DTXSID3059131RefChem:157882DTXCID4048981202-502-7
展开更多名称
乙醇酸甲甲基乙醇酯羥乙酸甲酯乙醇酸甲酯羟乙酸甲酯羟基乙酸甲酯羟基醋酸甲酯试剂级乙醇酸甲酯2-羟基乙酸甲酯乙醇酸甲酯/ARMGMethylglycolate,98%Hydroxy acetateMethyleglycolate2-hydroxyethanoateGlycolic acid methyl
methyl 2-hydroxyacetateMFCD00004667Hydroxyacetic Acid Methyl Ester2-hydroxyacetic acid methyl esterGlycolic Acid Methyl EsterMethyl 2-hydroxyethanoate124238-96-6EINECS 202-502-7

数据库标识

CAS
96-35-5
PubChem CID
66774
DTXSID
DTXSID3059131
UNII
7G7R729EJ0
EC Number
202-502-7
Nikkaji
J3.969A

性质

结构计算性质

XLogP
-0.5
极性表面积
46.5 Ų
氢键供体
1
氢键受体
3
可旋转键
2
重原子
6

实验与物化性质

Chemical ClassesOther Classes -> Esters, Other
CosmeticsCosmetic ingredients (Methyl Glycolate) -> CIR (Cosmetic Ingredient Review)
SpringerMaterials PropertiesCoriolis coupling
Physical DescriptionClear light yellow liquid; [Sigma-Aldrich MSDS]

物理化学性质

熔点
149 · 149-151 °C
沸点
149 · 149-151 °C(lit.)
密度
1.167 g/mL · 1.167 g/mL at 25 °C(lit.)
蒸气密度
3.12 · 3.12 (vs air)
蒸气压
17 mm · 17 mm Hg ( 52 °C)
折射率
20 · n20/D 1.417(lit.)

安全与法规

GHS分类

GHS Classification · 5 条

This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.

Warning

H227 (33.3%): Combustible liquid [Warning Flammable liquids]

P210, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory InformationAcetic acid, hydroxy-, methyl ester: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesFlam. Liq. 4 (33.3%)

毒理信息

Toxicity Summary · 2 条

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Methyl Glycolate...

Safe for use in cosmetics, with qualifications

安全数据

wgk
3
tsca
TSCA listed
存储类别
10 - Combustible liquids
安全说明
23-24/25
海关编码
29181990
危险品标志
Xi

化学与工业

用途与制造

UsesCIR ingredient: Methyl Glycolate
General Manufacturing InformationAcetic acid, 2-hydroxy-, methyl ester: ACTIVE
应用领域 · 3 条

简介羟乙酸甲酯以其独特的分子结构：同时具有H、羟基和酯基官能团，使得它兼有醇和酯的化学性质，能够发生羰化反应、水解反应、氧化反应等，成为一种重要的化工原料。

应用乙醇酸甲酯可被广泛应用于化工、医药、农药、饲料、香料及染料等许多领域。乙醇酸甲酯易溶于硝纤维素、醋酸纤维素、醋酸丙酸纤维素和聚乙酸乙烯酯中。它本身也是许多纤维素、树脂、橡胶的优良溶剂。乙醇酸甲酯用其它醇进行醇解能得到不同的酯。乙醇酸甲酯不仅在化工、医药、染料等诸多领域有较广泛的应用，更重要的是作为有机合成和药物合成的中间体。

用途用于有机合成，高档的清洁溶剂

制备方法

合成方法醛羰化一酯化合成法：在约70.9MPa和高温下，将甲醛水溶液与CO在浓硫酸或三氟化硼等催化剂作用下，先缩合生成乙醇酸。在将乙醇酸用甲醇酯化即得乙醇酸甲酯 。反应方程式为： 或者在碱性催化剂存在下，将甲醇和CO 反应生成透明的甲酸甲酯，然后甲酸甲酯与甲醛在路易斯催化剂或离子交换树脂存在的条件下生成乙醇酸甲酯。

上下游产品信息

试剂价格

A17870 · 25g
羟乙酸甲酯, 98%Methyl glycolate, 98% — 931元
41437 · 100g
乙醇酸甲酯Methyl glycolate, 98%, Thermo Scientific Chemicals — 2696元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

相关反应

194 条
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