N-羟乙基亚胺二乙酸 (HCID 7152)

名称与标识

首选名称: (2-Hydroxyethyl)iminodiacetic acid
IUPAC: 2-[carboxymethyl(2-hydroxyethyl)amino]acetic acid
中文名: N-羟乙基亚胺二乙酸
英文名: N-(2-Hydroxyethyl)iminodiacetic acid
分子式: C6H11NO5
分子量: 177.16

名称与别名

N-(2-Hydroxyethyl)iminodiacetic acid93-62-9Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-Ethanolamine-N,N-diacetic acid(2-Hydroxyethyl)iminodiacetic acid(Hydroxyethylimino)diacetic acid2-Hydroxyethylaminodiacetic acidHydroxyethylnitrilodiacetic acidN-(2-Hydroxyethyl)imidodiacetic acid2-Hydroxyethylamino diacetic acidBPQ4R5AF5KDTXSID4042177

展开更多名称

羟乙基亚氨基二乙酸N-羟乙基亚胺二乙酸N-羟乙基亚胺二乙酸/AR(2-羟乙基)替亚胺二乙酸N-(2-羟乙基)亚胺二乙酸N-(2-羟乙基)亚氨基二乙酸羟乙基亚氨基二乙酸(HEIDA)N-羟乙基亚胺二乙酸(HEIDA)N-(羧甲基)-N-(2-羟乙基)甘氨酸N-(2-羟乙基)亚氨基二乙酸HIDAusafdo-37USAF do-37ETHANOL DIGLYCINEIFLAB-BB F1019-00082,2'-((2-Hydroxyethyl)ethanolamine-n,n-diaceticacidn-2-hydroxyethyliminodiacetate

CHELEST EANSC-18474CHEBI:143268RefChem:825491N-2-HEIDAADTXCID2022177202-263-9Heida

数据库标识

CAS: 93-62-9
PubChem CID: 7152
DTXSID: DTXSID4042177
ChEBI: CHEBI:143268
UNII: BPQ4R5AF5K
EC Number: 202-263-9
Nikkaji: J55.322K

性质

结构计算性质

XLogP: -3.5
极性表面积: 98.1 Å²
氢键供体: 3
氢键受体: 6
可旋转键: 6
重原子: 12
形式电荷: 0
复杂度: 153

实验与物化性质

Physical DescriptionWhite solid; [Sigma-Aldrich MSDS]

物理化学性质

熔点: 178 °C · 178 °C (lit.)
沸点: 309.06 °C · 309.06°C (rough estimate)
密度: 1.4347 · 1.4347 (rough estimate)
蒸气压: 8.398 hPa · 8.398hPa at 21.1℃
折射率: 1.423 · 1.4230 (estimate)
储存条件: 2 · 2-8°C, protect from light
溶解度: 0.1 M · 0.1 M NaOH: 50 mg/mL, clear
酸度系数(pKa): 1 · pK1:2.2;pK2:8.65 (25°C,μ=0.1)
形态: powder to crystal
颜色: White to Almost white
水溶解性: 18.61 g/L · 18.61g/L at 25℃
BRN: 1780628 · 1780628
主要应用: peptide synthesis
InChI: InChI=1S/C6H11NO5/c8-2-1-7(3-5(9)10)4-6(11)12/h8H,1-4H2,(H,9,10)(H,11,12)
InChIKey: JYXGIOKAKDAARW-UHFFFAOYSA-N
SMILES: C(O)(=O)CN(CC(O)=O)CCO
LogP: -1.17 at · -1.17 at 25℃
CAS 数据库: 93 · 93-62-9(CAS DataBase Reference)
EPA化学物质信息: N-(2-Hydroxyethyl)iminodiacetic acid (93-62-9)

化学性质

白色颗粒状结晶。熔点168℃（180℃分解）。易溶于热水，微溶于冷水。

安全与法规

GHS分类

GHS Classification · 5 条

Danger

H302 (57.9%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (11.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (23.2%): Causes skin irritation [Warning Skin corrosion/irritation]；H318 (64.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H319 (23.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (22.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 190 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危害信息

Regulatory Information · 2 条

Chemical: Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-

Status: Active Update: 16-09-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/22258

Hazards SummaryIntraperitoneal LD50 (mouse) = 100 mg/kg; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See Iminodiacetic acid,

Hazard Classes and CategoriesAcute Tox. 4 (57.9%)；Skin Corr. 1B (11.6%)；Skin Irrit. 2 (23.2%)；Eye Dam. 1 (64.7%)；Eye Irrit. 2 (23.7%)；STOT SE 3 (22.6%)

法规信息

Regulatory Information · 2 条

Chemical: Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-

Status: Active Update: 16-09-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/22258

安全数据

wgk: 3
tsca: TSCA listed
RTECS号: AI1925000
存储类别: 11 - Combustible Solids
安全说明: 26-36
海关编码: 29252900
危险品标志: Xi
危险性类别: Eye Irrit. 2Skin Irrit. 2STOT SE 3
危险类别码: 36/37/38

化学与工业

用途与制造

General Manufacturing InformationGlycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-: ACTIVE

应用领域

用途N-羟乙基亚胺二乙酸是一种有用的有机合成化合物。

用途作络合剂。

制备方法

生产方法将60g氯乙酸溶于200ml水中，用25g碳酸钾中和后加入15g乙醇胺和40g碳酸钾，加热回流3h，冷却后用浓盐酸酸化至pH=2。静置冷却后析出N-羟乙基亚胺二乙酸结晶。经水重结晶，得成品22g，收率50%。

上下游产品信息

上游原料

乙醇胺氢氧化钾羟乙基亚胺二乙酸 2-溴乙醇亚氨基二乙酸

下游产品

N-(2-HYDROXYETHYL)GLYCINE

试剂价格

XW019362902 · 5g: N-羟乙基亚胺二乙酸N-(2-Hydroxyethyl)iminodiacetic Acid — 81元
H0489 · 5G: N-(2-羟乙基)亚氨基二乙酸N-(2-Hydroxyethyl)iminodiacetic Acid — 295元

供应商50 家

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

郑州阿尔法化工有限公司+86-18530059196 · [email protected]

韶远科技(上海)有限公司021-50795510 4000665055 · [email protected]

湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]

上海摩睿化学科技有限公司13382110328 15255501563 · [email protected]

关联笔记

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N-羟乙基亚胺二乙酸

基本信息