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环氧氯丙烷
1-氯-2 · 3-氯-1 · Α-表氯醇 · 环氧氯丙烷 · 环氧环戊烷 · 氯甲代氧丙环 · 3-环氧丙烷 · 2-环氧丙烷
标识与物理属性
| CAS No. | 106-89-8 |
|---|---|
| 分子式 | C3H5ClO |
| 平均分子量 | 92.52 g/mol |
| 单同位素质量 | 92.0028925 g/mol |
| SMILES | ClCC1CO1 |
| InChIKey | BRLQWZUYTZBJKN-UHFFFAOYSA-N |
| PubChem CID | 7835 |
| ChEMBL | CHEMBL1421613 |
| ChEBI | CHEBI:37144 |
| EC No. | 203-439-8 |
| DTXSID | DTXSID1020566 |
| 中文名 | 环氧氯丙烷 |
化学与物理性质
| XLogP | 0.5 |
|---|---|
| 极性表面积 | 12.5 |
| 氢键供体 | 0 |
| 氢键受体 | 1 |
| 可旋转键 | 1 |
| 重原子 | 5 |
| 形式电荷 | 0 |
| 复杂度 | 37 |
| LogP（油水分配系数） | log Kow = 0.450.26 |
| 气味 | Odor is sweet, pungent or chloroform-like ... generally perceived as a slightly irritating chloroformlike odorPungent, garlic-like odorlike chloroform. |
| 密度 | 1.18 to 1.801 at 68 °F (EPA, 1998)1.1750 at 25 °C/4 °CRelative density (water = 1): 1.21.175 @25 °C1.183 g/mL at 25 °C(lit.) |
| Viscosity | 0.0103 poise at 25 °C |
| Color/Form | Colorless liquid |
| 溶解性 | 50 to 100 mg/mL at 72 °F (NTP, 1992)Miscible with most organic solventsMiscible with alcohol, ether, chloroform, trichloroethylene, carbon tetrachlorideimmiscible with petroleum hydrocarbons.In water, 6.59X10+4 mg/L at 25 °C65.9 mg/mL at 25 °CSolubility in water, g/100ml at 20 °C: 665.9g/l6 g/100 mL (10 ºC) |
| 闪点 | 93 °F (EPA, 1998)88 °F88 °F (31 °C) (Closed cup)31 °C c.c. |
| 沸点 | 241.7 °F at 760 mmHg (EPA, 1998)117.9 °C116 °C242 °F117.9 °C @760 [mm Hg]115-117 °C(lit.) |
| Decomposition | When heated to decomp, emits toxic fumes of /hydrogen chloride/. |
| 熔点 | -54.4 to -14.1 °F (EPA, 1998)-25.6 °C-57.2 °C-48 °C-54 °F-57 °C |
| 蒸气密度 | 3.29 (EPA, 1998) - Heavier than airwill sink (Relative to Air)3.29 (Air = 1)Relative vapor density (air = 1): 3.23.2 (vs air) |
| 嗅觉阈值 | Odor Threshold Low: 0.08 [ppm]Odor Threshold High: 12.0 [ppm]Odor threshold from AIHASensory perception studies indicate that mean threshold for odor recognition is approximately 10 ppm ... @ 25 ppm it is recognized by majority of persons.Human Odor Perception: non perception 0.2 mg/cu mperception 0.3 mg/cu m |
| 比旋光度 | -1~+1°(D/20℃)(c=1,CH3OH) |
| 蒸气压 | 13.8 mm Hg ( 21.1 °C) |
| 折射率 | n20/D 1.438(lit.) |
| 储存条件 | Store below +30°C. |
| 形态 | Liquid |
| 颜色 | APHA: ≤20 |
| 比重 | 1.183 (20/4℃) |
| 爆炸极限 | 3.8-21%(V) |
| 热导率 | 0.15 W/(m·K) at 25 ℃ |
| 比热容 | Cp(liquid): 1.42 J/(g·K), at 25℃ |
| 凝固点 | -57.2℃ |
| Merck | 14,3611 |
| BRN | 79785 |
| 亨利常数 | 3.42(x 10-5 atmm3/mol) at 25 °C (static headspace-GC, Welke et al., 1998) |
| 暴露限值 | ACGIH TLV-TWA:0.1 ppm (0.38 mg/m3)OSHA PEL-TWA:5 ppm (19 mg/m³)NIOSH REL-STEL:(15 min) 19 mg/m3 (5 ppm) |
| 介电常数 | 22.9(20℃) |
| 稳定性 | Unstable. Flammable - note wide explosion limits and low flash point. |
| 主要应用 | cleaning productscosmeticsenvironmentalfood and beveragespersonal care |
| InChI | 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2 |
| InChIKey | BRLQWZUYTZBJKN-UHFFFAOYSA-N |
| SMILES | ClCC1CO1 |
| LogP（油水分配系数） | 0.45 at 20℃ |
| CAS 数据库 | 106-89-8(CAS DataBase Reference) |
| (IARC)致癌物分类 | 2A (Vol. 11, Sup 7, 71) 1999 |
| NIST化学物质信息 | Oxirane, (chloromethyl)-(106-89-8) |
| EPA化学物质信息 | Epichlorohydrin (106-89-8) |
化学性质
挥发的、不稳定的无色油状液体，有类似氯仿的气味。 与多数有机溶剂混溶，微溶于水。
安全与法规
| GHS 分类 | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]H301: Toxic if swallowed [Danger Acute toxicity, oral]H311: Toxic in contact with skin [Danger Acute toxicity, dermal]H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H331: Toxic if inhaled [Danger Acute toxicity, inhalation]H350: May cause cancer [Danger Carcinogenicity]P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P272, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P318, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1920) of reports. |
|---|---|
| 法规信息 | Chemical: Oxirane, (chloromethyl)-Hazard Traits - CarcinogenicityOcular ToxicityReproductive ToxicityRespiratory ToxicityAuthoritative List - CA TACsEC Annex VI CMRs - Cat. 1BIARC Carcinogens - 2AIRIS Carcinogens - B2NTP RoC - reasonableOEHHA RELsProp 65Report - regardless of intended function of ingredient in the productRegulation (EC) No 178/2002 (amended)Oxirane, 2-(chloromethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Oxirane, 2-(chloromethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 14-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15559Status: Cease Manufacture Update: 09-08-2010 https://echa.europa.eu/registration-dossier/-/registered-dossier/1262Status: Active Update: 26-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23282Oxirane, (chloromethyl)-: HSNO Approval: HSR000977 Approved with controls |
| 其他安全信息 | IMAP assessments - Oxirane, (chloromethyl)-: Environment tier I assessmentIMAP assessments - Oxirane, (chloromethyl)-: Human health tier II assessment |
| 运输标签（DOT） | Poison Flammable Liquid |
| 火灾危害 | When heated to decomposition, this compound evolves highly toxic fumes of phosgene and carbon monoxide. Reactive and incompatible with strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of iron and aluminumand compounds with an active hydrogen atom, including water. Unstable, avoid heat, contaminants, strong acids and bases, certain curing agents such as ethylenediamine. Hazardous polymerization may occur. (EPA, 1998)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)· Vapors may form explosive mixtures with air.· Vapors may travel to source of ignition and flash back.· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Vapor explosion and poison hazard indoors, outdoors or in sewers.· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.· Runoff to sewer may create fire or explosion hazard.· Containers may explode when heated.· Many liquids will float on water.Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 31 °C explosive vapour/air mixtures may be formed. |
| 火灾可能性 | Flammable liquid when exposed to heat or flame. |
| 健康危害 | This compound is caustic as both a liquid and gas. Irritation of the eyes and skin, and skin sensitization has been observed. Exposure to epichlorohydrin has caused inflammation of the lungs, asthmatic bronchitis, and liver and kidney damage. In acute poisonings, death may be caused by respiratory paralysis. (EPA, 1998)· TOXICmay be fatal if inhaled, ingested or absorbed through skin.· Inhalation or contact with some of these materials will irritate or burn skin and eyes.· Methyl chloroacetate (UN2295) is an eye irritant/lachrymator (causes flow of tears).· Fire will produce irritating, corrosive and/or toxic gases.· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.· Runoff from fire control or dilution water may cause environmental contamination. |
| 危害概述 | Epichlorohydrin is mainly used in the production of epoxy resins. Acute (short-term) inhalation exposure to epichlorohydrin in the workplace has caused irritation to the eyes, respiratory tract, and skin of workers. At high levels of exposure, nausea, vomiting, cough, labored breathing, inflammation of the lung, pulmonary edema, and renal lesions may be observed in humans. Chronic (long-term) occupational exposure of humans to epichlorohydrin in air is associated with high levels of respiratory tract illness and hematological effects. Damage to the nasal passages, respiratory tract and kidneys have been observed in rodents exposed to epichlorohydrin by inhalation for acute or chronic duration. An increased incidence of tumors of the nasal cavity has been observed in rats exposed by inhalation. EPA has classified epichlorohydrin as a Group B2, probable human carcinogen.Can cause severe skin burns and a skin sensitizerInhalation of vapor can cause lung edema and asthma-like reactions[ICSC] In high-dose animal studies, epichlorohydrin causes testicular damage and sterility. [Frazier, p. 340] Animals exposed in subchronic inhalation studies at 50 ppm show kidney damage and liver effects. TLV Basis is respiratory tract irritant[ACGIH] Suspected germ cell mutagen (3B)[MAK] Destructive to mucous membranes and upper respiratory tract[Sigma-Aldrich MSDS] Epichlorohydrin (UN2023) has warning of explosive polymerization[ERG 2016] |
| 运输编号与指南（DOT） | 2023 131P |
| 反应性基团 | Halogenated Organic CompoundsEpoxidesPolymerizable Compounds |
| 欧共体分类 | Symbol: TR: 45-10-23/24/25-34-43S: 53-45Note: E |
| 联合国分类 | UN Hazard Class: 6.1UN Subsidiary Risks: 3UN Pack Group: II |
| Special Reports | USEPAResponse To Public Comments On Draft Health Assessment Document for Epichlorohydrin (1983) EPA 600/8-83-032A Contract 68-02-4030Health Assessment Document: Epichlorohydrin (1983) EPA-600/8-83-032ANational Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Epichlorohydrin (106-89-8) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s082epic.pdf]European Commission, ESISIUCLID Dataset, 1-Chloro-2,3-epoxypropane (106-89-8) (2000 CD-ROM edition).[Available from, as of March 4, 2009: http://esis.jrc.ec.europa.eu/] |
| 消防 | If fire becomes uncontrollable, or containers are exposed to direct flames, evacuate for a radius of 1,500 feet. Isolate for one-half mile in all directions if tank car or truck is involved in fire.Epichlorohydrin may react violently with water.Use water spray, dry chemical, foam or carbon dioxide. Water spray may be used to dilute spills to non-flammable mixtures. If leak or spill has not ignited, use water spray to disperse the vapors. Keep fire-exposed containers cooled with water. (EPA, 1998)Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 急救措施 | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.Wear protective gloves when administering first aid. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Put clothes in sealable container. Refer immediately for medical attention.Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. |
| 泄漏应急措施 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· All equipment used when handling the product must be grounded.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· A vapor-suppressing foam may be used to reduce vapors.Small Spill· Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal.· Use clean, non-sparking tools to collect absorbed material.Large Spill· Dike far ahead of liquid spill for later disposal.· Water spray may reduce vapor, but may not prevent ignition in closed spaces. |
| 急救 | Warning: Effects may be delayed for several hours. Caution is advised.Signs and Symptoms of Acute Epichlorohydrin Exposure: Acute exposure to epichlorohydrin may result in nausea, vomiting, and abdominal pain. Liver and kidney effects may be observed. The respiratory tract may become irritated, dyspnea (shortness of breath) may occur, and in acute cases, respiratory paralysis has been observed. Central nervous system and respiratory depression have been noted. Facial swelling, mucosal irritation, dermatitis (red, inflamed skin), and eye irritation may also occur following exposure to epichlorohydrin.Emergency Life-Support Procedures: Acute exposure to epichlorohydrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.Inhalation Exposure:1. Move victims to fresh air. Emergency personnel should avoid self-exposure to epichlorohydrin.2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.4. Transport to a health care facility.Dermal/Eye Exposure:1. Remove victims from exposure. Emergency personnel should avoid self- exposure to epichlorohydrin.3. Remove contaminated clothing as soon as possible.4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.5. Wash exposed skin areas twice with soap and water.6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.7. Transport to a health care facility.Ingestion Exposure:1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of epichlorohydrin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to StepGeneral First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· Wash skin with soap and water.(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
| 安全储存 | Fireproof. Separated from strong oxidants, acids, bases, aluminium, zinc, amines and food and feedstuffs. Well closed. |
| Firefighting Hazards | Vapors are heavier than air and may travel to a source of ignition and flash back. |
| 暴露控制与个人防护 | · Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.687.0 [ppm] |
| 灭火程序 | Avoid use of dry chemical if fire occurs in container with confined vent. Containers may explode in fire because of polymerization.Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Fight fire from protected location or maximum possible distance. Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.If material on fire or involved in fire Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.Evacuation: If fire becomes uncontrollable or container is exposed to direct flame consider evacuation of one-third (1/3) mile radius. |
| 储存条件 | Separate from acids, alkalies, salts, water, and oxidizers. Store in a cool, dry, well-ventilated location. Inside storage should be in a standard flammable liquids storage warehouse, room, or cabinet./Store at/ ambient temperaturePRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/Epichlorohydrin should be stored in tightly closed, labeled containers in fire-proof, cool, dry rooms. Apply ventilation across the floor. Epichlorohydrin attacks steel in the presence of moisture. The compound should be stored away from strong acids and bases, zinc, aluminium, metal chlorides, alcohol-containing material, isopropylamine, trichloroethylene, and oxidizing agents. |
| 清理方法 | Remove all ignition sources. Ventilate area of spill or leak.For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in suitable location away from combustible materials.... It should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concentrations of epichlorhydrin vapors are permitted.PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/For more Cleanup Methods (Complete) data for EPICHLOROHYDRIN (8 total), please visit the HSDB record page. |
| 非火灾泄漏应对 | Excerpt from ERG Guide 131 [Flammable Liquids - Toxicpolymerization hazard]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors.SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024) |
| 处置方法 | [40 CFR 240-280, 300-306, 702-799 (7/1/2008)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U014, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Epichlorohydrin is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/For more Disposal Methods (Complete) data for EPICHLOROHYDRIN (8 total), please visit the HSDB record page. |
| Cancer Sites | GastrointestinalRespiratory[in animals: nasal cancer] |
| 靶器官 | RespiratoryEyes, skin, respiratory system, kidneys, liver, reproductive system |
| 生态毒性数值 | Minimum inhibitory concentrationSpecies: Microcystis aeruginosa (Blue algae)Conditions: static, 27 °C, pH 7.0Concentration: 6.0 mg/L for 8 daysEffect: cell multiplication /from table/Species: Scenedesmus quadricauda (Green algae)Concentration: 5.4 mg/L for 8 daysSpecies: Pseudomonas putida (Bacteria)Conditions: static, 25 °C, pH 7.0Concentration: 55 mg/L for 16 hrSpecies: Entosiphon sulcatum (Protozoa)Conditions: static, 25 °C, pH 6.9Concentration: 35 mg/L for 72 hrFor more Ecotoxicity Values (Complete) data for EPICHLOROHYDRIN (18 total), please visit the HSDB record page. |
| 环境归趋 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.45(2) and a regression-derived equation(3), indicates that epichlorohydrin is expected to have very high mobility in soil(SRC). Volatilization of epichlorohydrin from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), calculated from a vapor pressure of 16.4 mm Hg(4) and water solubility of 65,900 mg/L(5). The potential for volatilization of epichlorohydrin from dry soil surfaces may exist based upon the vapor pressure(4). Epichlorohydrin may undergo hydrolysis in moist soil surfaces based on a hydrolysis half-life of 8.2 days in distilled water(6). Epichlorohydrin achieved 3% of the theoretical BOD in a sewage sludge over a 5 day incubation period, but achieved 14% of the theoretical BOD following acclimation(7), suggesting that biodegradation in acclimated soils may be important(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.45(2) and a regression-derived equation(3), indicates that epichlorohydrin is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), calculated from its vapor pressure of 16.4 mm Hg(4) and water solubility of 65,900 mg/L(5). Using this estimated Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 19 hours and 12 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. The hydrolysis half-life of epichlorohydrin is 8.2 days in distilled water and 5.3 days in simulated seawater(8). Epichlorohydrin achieved 3% of the theoretical BOD in a sewage sludge over a 5 day incubation period, but achieved 14% of the theoretical BOD following acclimation(9)thus biodegradation in acclimated water may be important(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), epichlorohydrin, which has a vapor pressure of 16.4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase epichlorohydrin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 4.4X10-13 cu cm/molecule-sec at 25 °C(3). |
| 不良影响 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.Dermatotoxin - Skin burns.Skin Sensitizer - An agent that can induce an allergic reaction in the skin.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens.NTP Carcinogen - Reasonably anticipated to be a human carcinogen.ACGIH Carcinogen - Confirmed Animal. |
| 暴露途径 | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| 毒性概述 | IDENTIFICATION: Epichlorohydrin is a colorless liquid in which the vapor forms explosive mixtures in air. Phosgene, hydrogen chloride and carbon monoxide are liberated while burning. Acids, caustic solutions and halide salts initiate polymerization reactions. The compound is very reactive with metals such as zinc, aluminum, anhydrous metal halides, strong acids and bases along with alcohol containing materials. In the presence of moisture epichlorohydrin is corrosive to steel. Epichlorohydrin has a chloroform like odor. It is soluble in water. Epichlorohydrin is used for the manufacture of glycerine and unmodified epoxyresins. It is also used in the production of elastomers, glycidil ether, cross linked food starch, wet strength resins for the paper industry, water treatment resins, surfactants, ion exchange resins, plasticizers, dyestuffs, pharmaceutical products, emulsifiers, lubricants and adhesives. HUMAN EXPOSURE: On the basis of use patterns and the chemical and physical properties of epichlorohydrin, human exposure is mainly occupational, through vapor inhalation, direct skin contact and a slight exposure resulting from food consumption. Five human volunteers showed significant electroencephalogram changes in the voltage spikes of the alpha rhythm when they were exposed to a vapor of epichlorohydrin. Burning of the eyes and nasal mucosa was reported along with throat irritation. Seven cases of epichlorohydrin spills on the hands, thighs or feet have been described. In two cases epichlorohydrin was mixed with methanol. All spills resulted in protracted chemical burns with a latent period of between 10 minutes and several hours before the first symptoms appeared. Redness, swelling, edema, erosion and ulceration. One case was reported of a 39 year old man who inhaled a few deep breaths of epichlorohydrin vapor occured. Initially only a slight irritation of the eyes and throat was experienced with headache, nausea and vomitinglater chronic asthmatic bronchit |
| 生态毒性摘录 | /AQUATIC SPECIES/ The 14 day LC50 value of epichlorohydrin to the guppy (Poecilia reticulata) was determined. These data were investigated through the construction of a quantitative structure-activity relationship (QSAR). Both hydrophobicity and alkylating potency of the compound were found to be necessary parameters for the satisfactory description of the LC50 data. The log LC50 experimental data for epichlorohydrin was 0.85 umol/L as compared to the calculated QSAR value of 1.08 umol/L. |
| Signs and Symptoms | Cough. Sore throat. Burning sensation. Headache. Laboured breathing. Nausea. Shortness of breath. Vomiting. Tremor. Symptoms may be delayed.MAY BE ABSORBED! Redness. Pain. Burning sensation. Blisters. Serious skin burns.Pain. Redness. Loss of vision. Severe deep burns.Sore throat. Burns in mouth and throat. Headache. Nausea. Vomiting. Diarrhoea. Shock or collapse.irritation eyes, skin with deep painnausea, vomitingabdominal painresp distress, coughcyanosisreproductive effects[potential occupational carcinogen] |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-89-8] |
| Effluent Concentrations | Detected, not quantified in chemical industry effluent in Louisville, KY(1). Epichlorohydrin was identified, not quantified, in emissions from polyurethane carpet cushions(2). Atmospheric emissions of epichlorohydrin were reported as 479,000 lbs/yr in the US in a 1983 study(3). Epichlorohydrin was identified, not quantified, in sewage samples obtained from a municipal treatment plant which was also supplied with the pre-treated sewage from a chemical plant(4). |
| ICSC Environmental Data | The substance is harmful to aquatic organisms. |
| RCRA 要求 | U041As stipulated in 40 CFR 261.33, when epichlorohydrin, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). |
| TSCA 要求 | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Oxirane, (chloromethyl)- is included on this list. Effective date 10/4/82Sunset date: 10/4/92. |
| 大气标准 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Epichlorohydrin is produced, as an intermediate or a final product, by process units covered under this subpart.Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Epichlorohydrin is included on this list.Epichlorohydrin is a substance for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, from ambient air exposure to the substance. |
| CERCLA 应报告数量 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Epichlorohydrin is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1000 lbs. |
| 清洁水法要求 | Epichlorohydrin is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| DHS Chemicals of Interest (COI) | Epichlorohydrin120000Toxic chemical that can be released at a facility. |
| 州饮用水指南 | (FL) FLORIDA 3 ug/l(AZ) ARIZONA 3.5 ug/l(ME) MAINE 35 ug/l |
| Federal Drinking Water Standards | EPA Treatment Technique in lieu of MCL. |
| 水危害等级（WGK） | 3 |
| TSCA 清单状态 | TSCA listed |
| 毒性 | LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter) |
| RTECS 号 | TX4900000 |
| 包装类别 | II |
| 危险类别 | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralCarc. 1BEye Dam. 1Flam. Liq. 3Repr. 2Skin Corr. 1BSkin Sens. 1 |
| 储存类别 | 3 - Flammable liquids |
| 安全说明（S） | 53-45 |
| 海关编码 | 2910 30 00 |
| 自燃温度 | 779 °F |
| 危险品标志 | T |
| 危险类别码（R） | 45-10-23/24/25-34-43 |
| 毒害物质数据 | 106-89-8(Hazardous Substances Data) |
| 运输编号（UN） | UN 2023 |
| 立即危及生命和健康浓度 | 75 ppm |
急性毒性
口服- 大鼠 LD50: 90 毫克/ 公斤; 口服- 小鼠 LD50: 195 毫克/ 公斤
刺激数据
皮肤- 兔子 10 毫克/ 24小时; 眼睛- 兔子 100 毫克/ 24小时 中度
职业标准
TWA 10 毫克/ 立方米；STEL 20 毫克/立方米
爆炸物危险特性
与空气混合可爆
可燃性危险特性
遇明火、高温、氧化剂较易燃; 燃烧产生有毒氯化物烟雾
储运特性
库房通风低温干燥; 与氧化剂、酸类分开存放
灭火剂
干粉、二氧化碳、泡沫、1211灭火剂
用途与应用
概述
环氧氯丙烷为无色油状液体，有刺激性如醚和氯仿的气味，易燃，易挥发，有毒性和麻醉性。相对密度1.1812，熔点-25.6℃，沸点117.9℃，与乙醇、丙醇、乙醚、氯仿、丙酮、三氯乙烯及四氯化碳等许多有机溶剂混溶，易溶于苯，微溶于水，由于分子结构中含有活泼的氯原子和环氧基，所以化学性活泼，水解时先生成α-氯甘油，再生成甘油。能发生开环反应，可以生成丙二醇及丙三醇;与醇及苯酚反应可以生成醚;与胺类反应可生成缩水甘油胺;与羧酸反应可以生成酯;可以自聚;与醛(或酮)反应可以生成二恶茂烷。 环氧氯丙烷的主要用途是用于制造双酚A缩水甘油醚。即环氧氯丙烷在烧碱存在下与双酚A缩合成为双酚A氯醇醚，然后以烧碱脱去其氯化氢，即制得双酚A缩水甘油醚。 环氧氯丙烷主要用于合成甘油和环氧树脂，也可用于制造环氧树脂、氯醇橡胶、硝化甘油炸药、玻璃钢、农药、医药、表面活性剂、涂料、胶粘剂、增塑剂、增强塑料及电绝缘制品等。还可用作油漆、纤维素酯、纤维素醚和树脂等的溶剂。 以上信息由ChemicalBook的andy编辑整理。
用途
主要用于制备甘油、环氧树脂、氯醇橡胶、聚醚多元醇，是生产甘油及缩水甘油衍生物的重要原料，还用作溶剂
用途
用作有机溶剂
用途
环氧氯丙烷是杀鼠剂鼠甘伏的中间体，也是环氧树脂、合成甘油和其他化工产品的中间体。
用途
环氧氯丙烷是合成甘油中间体，也是环氧树脂、硝化甘油炸药、玻璃钢、电绝缘制品的主要原料。并用作纤维素酯、树脂和纤维素醚的混剂。也是生产表面活性剂、医药、农药、涂料、胶粘剂、离子交换树脂、增塑剂、甘油衍生物、缩水甘油衍生物以及氯醇橡胶的原料。以环氧氯丙烷与双酚A为主要原料制取的各类环氧树脂具有粘合性高、收缩性小、耐化学腐蚀、稳定性好等特点，广泛用作涂料、粘合剂、增强材料和浇铸材料等。以环氧氯丙烷为原料生产的氯醇橡胶是橡胶的新品种，在一般油和普通溶剂中不易膨胀，在低温无增塑剂存在下具有较大的挠性，具有优于丁腈、氯丁和丁基橡胶的某些特有的功能。
用途
用作有机合成的原料，也用作溶剂、增塑剂、表面活性剂等
用途
有机合成的原料;也用作溶剂、增塑剂、表面活性剂.要用于制备甘油、环氧树脂、氯醇橡胶、聚醚多元醇，是生产甘油及缩水甘油衍生物的重要原料。
用途
有机合成的原料;有机溶剂（树脂、树胶、纤维素醚等的溶剂）;也用作增塑剂、表面活性剂等
制备与合成方法
生产方法
工业上主要用丙烯氯化法制取。丙烯和氯气进行高温氯化得到烯丙基氯，再经次氯酸化制取二氯丙醇，进而皂化制得环氧氯丙烷。原料消耗定额：丙烯（100%）640kg/t、氢氧化钠（100%）150kg/t、氯气2070kg/t、副产D-D混剂140kg/t、氢氧化钙（100%）1020kg/t。
生产方法
其制备方法是以丙烯为原料，在500℃氯化生成氯丙烯，氯丙烯在25～35℃温度下，与次氯酸反应，得到2，3-二氯丙醇和1，2-二氯丙醇，然后将该混合物加入20％石灰乳进行皂化，反应温度45～55℃，而得环氧氯丙烷。