对乙氧基苯胺

4-Ethoxyaniline

HCID 9076CAS 156-43-4

基本信息

标准SMILES
CCOc1ccc(N)cc1
InChIKey
IMPPGHMHELILKG-UHFFFAOYSA-N
分子式
C8H11NO
平均分子量
137.18 g/mol
单同位素质量
137.08406397

概述

P-phenetidine is a colorless to dark red liquid. (NTP, 1992)

名称与标识

首选名称
4-Ethoxyaniline
IUPAC
4-ethoxyaniline
中文名
对乙氧基苯胺
英文名
Phenetidine
分子式
C8H11NO
分子量
137.18

名称与别名

p-Phenetidine4-ETHOXYANILINE156-43-4Phenetidine4-Aminophenetolep-Ethoxyanilinep-Phenetidinp-AminophenetoleBenzenamine, 4-ethoxy-Phenethidine1-Amino-4-ethoxybenzeneAniline, p-ethoxy-
展开更多名称
胺苯乙醚乙氧苯胺對乙氧苯胺間乙氧苯胺氨基苯乙醚对氨基苯乙醚对乙氧基苯胺对氨基本乙醚4-氨基苯乙醚4-乙氧基苯胺PARA PHENETIDINEethoxyanilinep-Aminophenolethylether4-EthoxyanilinPARA-PHENETIDIN
4-Phenetidine4-AminoethoxybenzeneEthyl p-aminophenolDTXSID00258649TSL224ZSECP 5685NSC-3116DTXCID505864

数据库标识

CAS
156-43-4
PubChem CID
9076
DTXSID
DTXSID0025864
ChEMBL
CHEMBL250969
ChEBI
CHEBI:85505
UNII
9TSL224ZSE
EC Number
205-855-5
Nikkaji
J2.032J

性质

结构计算性质

XLogP
1.2
极性表面积
35.3 Ų
氢键供体
1
氢键受体
2
可旋转键
2
重原子
10

实验与物化性质

Chemical ClassesNitrogen Compounds -> Amines, Aromatic
SpringerMaterials PropertiesBoiling point
LogP · 2 条

1.24

1.24

Density · 3 条

1.0652 at 61 °F (NTP, 1992) - Denser than water; will sink

1.1 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.0

Solubility · 2 条

5 to 10 mg/mL at 68 °F (NTP, 1992)

Solubility in water, g/100ml at 20 °C: 2 (moderate)

Flash Point · 2 条

240 °F (NTP, 1992)

120 °C c.c.

物理化学性质

熔点
2 · 2-5 °C(lit.)
沸点
250 °C · 250 °C(lit.)
密度
1.065 g/mL · 1.065 g/mL at 25 °C(lit.)
蒸气压
2.93 Pa · 2.93Pa at 25℃
折射率
20 · n20/D 1.559(lit.)
闪点
240 °F · 240 °F

化学性质

无色油状可燃液体。暴露于空气和日光中逐渐变成红色至棕色。 不溶于水和无机酸,溶于乙醇、乙醚和氯仿等。

安全与法规

GHS分类

GHS Classification · 6 条

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

危害信息

Regulatory Information · 4 条

Chemical: Benzenamine, 4-ethoxy-

Benzenamine, 4-ethoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenamine, 4-ethoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/10853

Phenetidine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzenamine, 4-ethoxy-: Human health tier II assessment
DOT LabelPoison
Fire Hazards · 2 条

This compound is combustible. (NTP, 1992)

Combustible.

Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis and irritation of the alimentary tract.
Hazards Summary · 1 条

An eye irritant; May induce methemoglobinemia; [ICSC] Causes methemoglobinemia in repeated-dose oral studies of rats; [RTECS] Toxic by ingestion, inhalation, and skin absorption; May cause contact irritation, cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis, and alimentary tract irritation; [NTP] Case report of methemoglobinemia from occupational exposure; Sensitizing in 2 of 3 maximization tests of guinea pigs; Not a lung sensitizer in guinea pigs; Some evidence of skin sensitization in humans; [IUCLID] A strong eye irritant; May cause skin sensitization; Harmful by ingestion, inhalation, and skin absorption; Suspected mutagen; [Alfa Aesar MSDS] See m-Phenetidine. See p-Anisidine.

安全与防护

Fire Fighting · 2 条

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use powder, alcohol-resistant foam, water spray, carbon dioxide.

First Aid Measures · 4 条

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth. Seek medical attention if you feel unwell.

First Aid · 1 条

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Safe StorageSeparated from strong oxidants and food and feedstuffs.
Nonfire Spill Response · 1 条

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Spillage Disposal · 1 条

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

毒理信息

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Exposure RoutesThe substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Signs and SymptomsRedness.
ICSC Environmental DataEnvironmental effects from the substance have not been investigated adequately.
Toxicity DataLCLo (rat) = 487 mg/m3/4hr

安全数据

F
8-10
wgk
1
tsca
TSCA listed
毒性
LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70
RTECS号
SI6465500
hazard_note
Irritant

毒性防护

急性毒性口服-大鼠 LD50: 540 毫克/公斤; 口服-小鼠 LD50: 530 毫克/公斤

刺激数据皮肤-兔子 500 毫克 轻度; 眼睛-兔子 100 毫克 中度

包装储运 · 3 条

可燃性危险特性明火可燃; 受热放出有毒苯胺类气体

储运特性库房通风低温干燥; 与食品原料分开储运

灭火剂雾状水、二氧化碳、砂土、干粉

化学与工业

用途与制造

UsesUsed to make acetophenetidine, phenocoll, dulcin, and dyes; [Merck Index] Used to make fine chemicals; [ExPub: ECHA REACH Registrations]
U.S. Production2023: 50,000 - <250,000 lb
Industry UsesOther
General Manufacturing Information · 2 条

Explosives Manufacturing

Benzenamine, 4-ethoxy-: ACTIVE

应用领域 · 3 条

用途用作医药、染料、食品防腐剂、饲料添加剂、橡胶防老剂的中间体

用途该品用于生产橡胶防老剂AW,即6-乙氧基-2,2,4-三甲基-1,2-二氢化喹啉。也用于饲料和食品,可防止脂肪、蛋白质在贮存过程中氧化变质,还用于维生素A和维生素E等药品的保存。作为饲料和食品抗氧化剂时,称乙氧喹([91-53-27])。在医药方面,用于生产解热镇痛药非那西丁、安痨息和消毒防腐药利凡诺。在染料方面,该品是色酚AS-VL、茜素红5G和坚牢酸性蓝R的中间体。

用途测定铜、铁、锰、钒、锌、铬酸盐和氰化物。氧化还原指示剂。有机合成。染料制造。

制备方法 · 1 条

生产方法1.由对硝基苯乙醚([100-29-8])还原而得。将硫化钠、硫磺加水升温至138-142℃,溶液静置澄清后加入还原锅内。加热搅拌,于5-6.5h内均匀缓慢加完对硝基苯乙醚,在132-134℃常压反应3h,在138-140℃加压(0.1MPa以下)反应10-12h。加水搅拌后静置1h。分去下层硫代硫酸钠母液,上层油层分净残渣,减压蒸馏,收集168-170℃(5.33kPa)馏分,得含量99%的对乙氧基苯胺。收率95%以上。也可采用加氢还原,以镍作催化剂,在130-140℃,0.6MPa压力下通氢反应,对硝基苯乙醚还原为对乙氧基苯胺。另外,以硝基苯为原料,在硫酸存在下,采用氧化镍为催化剂,二甲亚砜为促进剂,与无水乙醇乙氧基化,并还原一步制得对乙氧基苯胺。2.对氨基苯酚法 经与氯乙烷反应制得。

试剂价格

P0090 · 25G
对乙氧基苯胺p-Phenetidine — 120元
P0090 · 500G
对乙氧基苯胺p-Phenetidine — 440元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
玉门市海鼎化工有限公司09376971818 13079324666 · [email protected]

相关反应

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