对氟硝基苯 (HCID 9590)

名称与标识

首选名称: p-Fluoronitrobenzene
IUPAC: 1-fluoro-4-nitrobenzene
中文名: 对氟硝基苯
英文名: 4-Fluoronitrobenzene
分子式: C6H4FNO2
分子量: 141.1

名称与别名

p-FluoronitrobenzeneRefChem:4328404-Fluoronitrobenzene1-FLUORO-4-NITROBENZENE350-46-9p-Nitrofluorobenzene4-NitrofluorobenzeneBenzene, 1-fluoro-4-nitro-4-Fluoro-1-nitrobenzene1-Nitro-4-fluorobenzene178603-76-41-Fluoro-4-nitro-benzene

展开更多名称

硝基氟苯對硝基氟苯对氟硝基苯4-硝基氟苯4-氟硝基苯对氟硝基苯99%1-氟-4-硝基苯对氟硝基苯(易制爆)尼达尼布杂质67对照品4-氟硝基苯, 用于合成4-FluornitrobenzolFluoro-4-nitrobenzFluoronitrobenzene3p-fluoromitrobenzene

MFCD000072824-nitro-1-fluorobenzeneNSC 10281para-fluoronitrobenzene1,4-FluoronitrobenzeneBenzene, 1-fluoro-4-nitro-, labeled with carbon-14 (9CI)A2M2FH7XHHNSC-10281

数据库标识

CAS: 350-46-9
PubChem CID: 9590
DTXSID: DTXSID9022025
ChEMBL: CHEMBL163729
UNII: A2M2FH7XHH
EC Number: 206-502-8
Nikkaji: J47.809A

性质

结构计算性质

XLogP: 1.8
极性表面积: 45.8 Å²
氢键供体: 0
氢键受体: 3
可旋转键: 0
重原子: 10
形式电荷: 0
复杂度: 126

实验与物化性质

Chemical ClassesNitrogen Compounds -> Nitros, Aromatic

SpringerMaterials Properties13C nuclear magnetic resonance spectrum

Density1.3300 @ 20 °C/4 °C

Color/FormYELLOW NEEDLES

SolubilitySOL IN ALCOHOL, ETHER; INSOL IN WATER

Boiling Point206-207 °C

物理化学性质

熔点: 21 °C · 21 °C (lit.)
沸点: 205 °C · 205 °C (lit.)
密度: 1.33 g/mL · 1.33 g/mL at 25 °C (lit.)
蒸气密度: 1 · >1 (vs air)
蒸气压: 5.5 mm · 5.5 mm Hg ( 70 °C)
折射率: 20 · n20/D 1.531(lit.)
闪点: 182 °F · 182 °F
储存条件: Sealed in dry,Room Temperature
溶解度: Chloroform (Slightly), Methanol (Slightly)
形态: Liquid After Melting
颜色: deep greenish-yellow
比重: 1.33 · 1.330
水溶解性: Insoluble in water.
BRN: 606923 · 606923
稳定性: Stable. Combustible. Incompatible with strong oxidizing agents.
InChI: 1S/C6H4FNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
InChIKey: WFQDTOYDVUWQMS-UHFFFAOYSA-N
SMILES: [O-][N+](=O)c1ccc(F)cc1
LogP: 1.8 at · 1.8 at 20℃
CAS 数据库: 350 · 350-46-9(CAS DataBase Reference)
NIST化学物质信息: 1 · Benzene, 1-fluoro-4-nitro-(350-46-9)
EPA化学物质信息: p-Fluoronitrobenzene (350-46-9)

化学性质

低温时为结晶。熔点为21℃，沸点为205℃，闪点83℃。

安全与法规

GHS分类

GHS Classification · 5 条

This chemical does not meet GHS hazard criteria for 1% (1 of 102) of reports.

Danger

H302 (88.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 102 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 3 条

Chemical: Benzene, 1-fluoro-4-nitro-

Status: Active Update: 13-08-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/7274

1-Fluoro-4-nitrobenzene: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryEmergency treatment: Methemoglobinemia; [HSDB] An irritant; [MSDSonline]

Hazard Classes and CategoriesAcute Tox. 4 (88.2%)

毒理信息

Ecotoxicity ValuesLC50 Pimephales promelas (fathead minnow) 28.4 mg/l 96 hr flow-through bioassay, wt 0.12 g, water hardness 45.5 mg/l CaCO3, temp: 25 +/- 1 °C, pH 7.5, dissolved oxygen greater than 60% of saturation

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Toxicity DataLC50 (rat) = 2,600 mg/m3/4h

安全数据

wgk: 1
tsca: TSCA listed
RTECS号: DA1400000
hazard_note: Toxic/Irritant
包装类别: III
危险等级: 6.1
存储类别: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
安全说明: 36-36/37
海关编码: 29049085
危险品标志: Xn,T,Xi
危险性类别: Acute Tox. 3 InhalationAcute Tox. 4 DermalAcute Tox. 4 OralSTOT RE 2
危险类别码: 20/21/22-33
毒害物质数据: 350-46-9(Hazardous Substances Data)
危险品运输编号: UN 2811 6.1/PG 3

毒性防护

急性毒性口服-大鼠 LDL0: 250 毫克/公斤

包装储运 · 3 条

可燃性危险特性明火可燃; 燃烧产生有毒氮氧化物和氟化物烟雾

储运特性库房通风低温干燥; 与氧化剂、食品添加剂分开存放

灭火剂雾状水、泡沫、二氧化碳、砂土

化学与工业

药理信息

Metabolism/MetabolitesYIELDS N-ACETYL-S-(P-NITROPHENYL)-L-CYSTEINE, P-FLUOROANILINE & P-NITROPHENOL IN RABBITS: BRAY & JAMES, BIOCHEM J 66: 45 (1957); BRAY ET AL, BIOCHEM J 68: 561 (1958). /FROM TABLE/

用途与制造

Uses · 3 条

Used as a component in hair dyes; [HSDB]

Dressing Hair [Category: Other]

A COMPONENT OF HAIR DYES

General Manufacturing InformationBenzene, 1-fluoro-4-nitro-: ACTIVE

应用领域 · 4 条

简介对氟硝基苯是芳基氟化的结构单元，是用于合成许多工业上有用的化合物的常用中间体。它用于制备新型可溶性芳香族聚酰亚胺，例如1,3,5-三（4-氨基苯氧基）苯（TAB）。

用途对氟硝基苯是一种芳基氟化的结构单元，是一种常见的中间体，用于合成许多工业有用的化合物。用于制备新型可溶性芳香族聚酰亚胺，如 1,3,5-三(4-氨基苯氧基)苯 (TAB)。

用途诺氟沙星（氟哌酸）的中间体。

用途用作医药、农药及染料中间体

制备方法

生产方法用氟苯以混酸硝化制得。

试剂价格

A11057 · 2500g: 1-氟-4-硝基苯1-Fluoro-4-nitrobenzene — 3431元
11949 · 500g: 1-氟-4-硝基苯1-Fluoro-4-nitrobenzene, 99%, Thermo Scientific Chemicals — 3308元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]

杭州创引化工科技有限公司0571-87086220 13516718938 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

关联笔记

加载中…

对氟硝基苯

基本信息