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7-氨基吲唑 → 4,5,6,7-四氢-1H-吲唑-7-胺
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 7-氨基吲唑 | HCID 88901 | — |
| 催化剂 | 铑 | HCID 23948 | — |
| 溶剂 | 乙醇 | HCID 702 | — |
| 产物 | 4,5,6,7-四氢-1H-吲唑-7-胺 | HCID 21941962 | 28% |
反应步骤
Combine 1H-indazol-7-ylamine (5.0 g, 37.6 mmol) and 5% Rh/C (2.45 g) in ethanol (120 mL) and heat at 120° C. for 48 hours under ˜1000 psi H2. Cool the reaction and filter through hyflo. Remove the solvent in vacuo and purify the crude product with 5% 2 M NH3 in MeOH in CH2Cl2 to afford 1.43 g (28%) of the titled product. MS (m/z): 138 (M+1).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07981918B2 |
| 来源数据集 | uspto-grants-2011_07 |
| ORD ID | ord-0c2ef847358947b4850acc0bc880c4ca |
| 来源说明 | uspto-grants-2011_07 |