四氢吡咯 → 4-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine

HRID 1019557

反应方程式

HRID 1019557 反应方程式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1.[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH3:9][O:8][C:6]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=[C:2]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:7]=1

参与物

3

反应物 2

HCID 31268四氢吡咯HCID 441196732-氯-4-甲氧基-5-硝基吡啶

产物 1

HCID 574315184-Methoxy-5-nitro-2-(pyrrolidin-1-yl)pyridine收率 46.9%

实验过程

The method described in Stage 12.1 is followed, starting from 5.4 g (28.64 mmol) of 2-chloro-4-methoxy-5-nitropyridine (WO2003/080610) and 4.53 g (63 mmol) of pyrrolidine. The product obtained is, in this case, purified by chromatography on a silica column, eluting with a mixture of heptane and ethyl acetate. In this way we isolate 3 g of the expected product.

后处理

  1. customThe product obtained
  2. custompurified by chromatography on a silica column
  3. washeluting with a mixture of heptane and ethyl acetate

来源与证据

ORD记录
ord-13083dc02c234193accf934a72a1ac84
来源数据集
uspto-grants-2014_05
专利号
US08716272B2

关联笔记

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