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3-吡啶-2-基-丙酸 → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 3-吡啶-2-基-丙酸 | HCID 564292 | — |
| 反应物 | tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate | HCID 66975002 | — |
| 产物 | N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride | HCID 66976608 | — |
反应步骤
Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 3-(pyridin-2-yl)propanoic acid, and by a method similar to that of Example 39, the title compound was obtained.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US08722662B2 |
| 来源数据集 | uspto-grants-2014_05 |
| ORD ID | ord-84e4f34e7f9840ddae85facd091dd078 |
| 来源说明 | uspto-grants-2014_05 |