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氯化铵 → HCID 178418294，化合物
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 氯化铵 | HCID 25517 | — |
| 反应物 | 碳酸氢钠 | HCID 516892 | — |
| 反应物 | 3-溴-2,4-二氯吡啶 | HCID 15683981 | — |
| 反应物 | HCID 178418405 | HCID 178418405 | — |
| 溶剂 | N-甲基吡咯烷酮 | HCID 13387 | — |
| 产物 | HCID 178418294 | HCID 178418294 | — |
反应步骤
2.27 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 2.6 g (15 mmol) of cis-4-phenylcyclohexylamine and 0.1 g of ammonium chloride are heated at 120° C. for 10 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated sodium hydrogencarbonate solution is added and the reaction product is extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.9 g (52%); m.p. 105° C.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05723450 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-d3878873efe84db9b86c10bc3e0d832a |
| 来源说明 | uspto-grants-1998_03 |