硝酸钾 → 5-硝基吲唑-3-羧酸

HRID 1038003

反应方程式

HRID 1038003 反应方程式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[N:2]1.[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[N+:13]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[C:3]2[C:10]([OH:12])=[O:11])([O-:15])=[O:14]

参与物

4

反应物 2

HCID 24434硝酸钾HCID 78250吲唑-3-羧酸2 次

产物 1

HCID 71446525-硝基吲唑-3-羧酸收率 77.8%

试剂、催化剂与溶剂 1

HCID 1118四氧化硫溶剂

实验过程

To a suspension of indazole-3-carboxylic acid (compound 53, 3.0 g, 18 mmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried and concentrated to give compound 54 (2.9 g) as the major isomer.

后处理

  1. extractionextracted three times with ethyl acetate
  2. washThe combined organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated

来源与证据

ORD记录
ord-fb4db22b2cdb4767bbd69603836df4b1
来源数据集
uspto-grants-2013_10
专利号
US08546404B2

关联笔记

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