4-羟基扁桃酸 → 4-羟基扁桃酸乙酯

HRID 1071777

反应方程式

HRID 1071777 反应方程式
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[C:13]1(C)C=CC(S(O)(=O)=O)=C[CH:14]=1.C([O-])(O)=O.[Na+]>C(O)C.O>[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([O:9][CH2:13][CH3:14])=[O:8])=[CH:4][CH:3]=1

参与物

6

反应物 3

HCID 3284-羟基扁桃酸HCID 6101对甲苯磺酸HCID 516892碳酸氢钠

产物 1

HCID 1113574-羟基扁桃酸乙酯收率 288%

试剂、催化剂与溶剂 2

HCID 702乙醇溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
50 °C

实验过程

A mixture of 5 g of 4-hydroxymandelic acid and 1.28 g of p-toluenesulfonic acid in 200 ml of ethanol is heated at 50° C. for 4 hours. The mixture is poured into saturated aqueous NaHCO3 solution, and a white precipitate is formed. The mixture is diluted with water until the precipitate disintegrates, and then is extracted with diethyl ether. The organic phases are dried over sodium sulfate. Filtration and evaporation of the solvent give ethyl 4-hydroxymandelate (4.2 g, 82%) as a pale yellowish solid.

后处理

  1. customa white precipitate is formed
  2. extractionis extracted with diethyl ether
  3. dry with materialThe organic phases are dried over sodium sulfate
  4. filtrationFiltration and evaporation of the solvent

来源与证据

ORD记录
ord-483957f9c4454e988f199e2119f4489a
来源数据集
uspto-grants-2005_06
专利号
US06906113B2

关联笔记

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