参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 氯化亚锡 | HCID 24479 | — |
| 反应物 | 4-氨基-2,3-二甲基苯甲 酸 | HCID 2762777 | — |
| 反应物 | 亚硝酸钠 | HCID 23668193 | — |
| 溶剂 | 海萝胶 | HCID 313 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 产物 | 2,3-Dimethyl-4-hydrazinobenzoic acid hydrochloride | HCID 70244582 | 93.7% |
反应步骤
A solution of 1.87 g of NaNO2 in 7 ml of water is added slowly to a solution, cooled to -5° C., of 4.5 g of 4-amino-2,3-dimethylbenzoic acid in 135 ml of concentrated HCl. After 2 hours of stirring at -5° C., a solution of 25 g of SnCl2 ·2H2O in 250 ml of concentrated HCl is added at -10° C., and the mixture is stirred for 30 minutes at -5° C. and then 2 hours at RT. The mixture is filtered, and the precipitate is washed with 5 ml of concentrated HCl and dried under a stream of dry nitrogen and then under vacuum to obtain 5.5 g of expected product.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US05723483 |
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| 来源数据集 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-70a25d6a367f495c9c26f59a04ae0cc2 |
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| 来源说明 | uspto-grants-1998_03 |
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