聚(苯乙烯-二乙烯苯) → benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine

HRID 1163440

反应方程式

HRID 1163440 反应方程式
Cl[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[N:11][NH:12]2)=[CH:8][CH:7]=1.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN(C=O)C>[CH2:21]([NH:28][C:2]1[CH:3]=[C:4]([O:5][C:6]2[CH:14]=[C:13]3[C:9]([CH:10]=[N:11][NH:12]3)=[CH:8][CH:7]=2)[CH:15]=[CH:16][C:17]=1[N+:18]([O-:20])=[O:19])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参与物

4

反应物 2

HCID 7504聚(苯乙烯-二乙烯苯)HCID 684463516-(3-chloro-4-nitrophenoxy)-1H-indazole

产物 1

HCID 68445941benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

反应条件

温度
100 °C

实验过程

A stirred solution of the nitro compound (2 mmol) in DMF (4 mL) was added with benzylamine (4 mmol) and contents were heated at 100° C. for 6 h. The reaction mixture was cooled to RT and the contents were poured onto ice cold water with vigorous stirring. The solid formed was collected by filtration, washed with water, and dried in vacuo. The residue obtained was purified on silica gel column chromatography using hexane/EtOAC as eluent to provide the product, benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine as a yellow solid.

后处理

  1. temperatureThe reaction mixture was cooled to RT
  2. additionthe contents were poured onto ice cold water with vigorous stirring
  3. customThe solid formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried in vacuo
  7. customThe residue obtained
  8. customwas purified on silica gel column chromatography

来源与证据

ORD记录
ord-d7cc111a1cf0407094d457dda9525ea0
来源数据集
uspto-grants-2010_10
专利号
US07820821B2

关联笔记

加载中…