四氢吡咯 → 6-(1-吡咯烷)烟酰甲醛

HRID 1186355

反应方程式

HRID 1186355 反应方程式
F[C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1.[NH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1>O1CCCC1>[N:10]1([C:2]2[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1

参与物

4

反应物 2

HCID 31268四氢吡咯HCID 164142462-氟吡啶-5-甲醛

产物 1

HCID 27947756-(1-吡咯烷)烟酰甲醛收率 84.5%

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

反应条件

温度
60 °C

实验过程

6-Fluoro-3-pyridinecarboxaldehyde (152 mg, 1.22=01) was dissolved in tetrahydrofuran (3.0 mL). To this, pyrrolidine (507 μL, 6.08 mmol) was added under a nitrogen atmosphere at room temperature and the mixture was stirred at the same temperature for 2 hours and successively at 60° C. for 5 hours. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give 6-(pyrrolidin-1-yl)-3-pyridinecarboxaldehyde (181 mg, yield: 84%).

后处理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)

来源与证据

ORD记录
ord-2e99f33994db471c9e54fae6db85b2d4
来源数据集
uspto-grants-2014_03
专利号
US08673908B2

关联笔记

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