醋酸 → 7-溴-4,4-二甲基-1-四氢萘酮

HRID 1213

反应方程式

HRID 1213 反应方程式
C(O[C:5](=[O:7])[CH3:6])(=O)C.C(O)(=O)C.[Br:12][C:13]1[CH:14]=C2[C:20](=[CH:21][CH:22]=1)[C:19]([CH3:24])([CH3:23])[CH2:18][CH2:17]C2>C1C=CC=CC=1.[O-2].[O-2].[O-2].[Cr+6]>[Br:12][C:13]1[CH:14]=[C:6]2[C:20]([C:19]([CH3:23])([CH3:24])[CH2:18][CH2:17][C:5]2=[O:7])=[CH:21][CH:22]=1

参与物

6

反应物 3

HCID 176醋酸HCID 7918乙酐HCID 105860636-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene2 次

产物 1

HCID 107533577-溴-4,4-二甲基-1-四氢萘酮

试剂、催化剂与溶剂 2

HCID 10219390三氧化铬催化剂HCID 241苯溶剂

实验过程

To a cold mixture (0° C.) of 209 g (200 mmol) of chromium trioxide, 100 ml (1.06 mol) of acetic anhydride and 200 ml (3.5 mol) of acetic acid was added a solution of 10 g (41.8 mmol) of 6-bromo-1,2,3,4-tet-rahydro-1,1-dimethylnaphthalene (Compound F) in 125 ml of benzene. The reaction mixture was stirred for 1 hour, quenched with ice cold water and extracted with Et2O (3×100 ml). The organic layer was dried over MgSO4, concentrated in vacuo, and purified by column chromatography (silica, 10% EtOAc-hexane) to give the title compound as a white solid.

后处理

  1. customquenched with ice cold water
  2. extractionextracted with Et2O (3×100 ml)
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated in vacuo
  5. custompurified by column chromatography (silica, 10% EtOAc-hexane)

来源与证据

ORD记录
ord-0f2e1f01e7ab4687bdbd97f9472f7215
来源数据集
uspto-grants-1998_03
专利号
US05723620

关联笔记

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