乙醇 → 4-氨基-间苯二甲酸

HRID 1247177

反应方程式

HRID 1247177 反应方程式
CCO.[N+:4]([C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[C:16]([OH:18])=[O:17])([O-])=O>[Pd].CC(O)=O>[NH2:4][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[C:16]([OH:18])=[O:17]

参与物

5

反应物 2

HCID 702乙醇HCID 30624384-硝基苯基-1,3-二甲酸

产物 1

HCID 113558524-氨基-间苯二甲酸收率 75.1%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 176醋酸溶剂

实验过程

Into 20 mL EtOH and 20 mL HOAc was dissolved 2 g (9.48 mmol) 4-nitroisophthalic acid, and the solution was subjected to hydrogenation at atmospheric conditions over 1 g of 5% Pd on carbon. After 16 h, mixture was filtered, and filtrate was evaporated. The residue crystallized from methylene chloride-hexane, giving 1.29 g (75%) crystalline desired intermediate.

后处理

  1. filtrationmixture was filtered
  2. customfiltrate was evaporated
  3. customThe residue crystallized from methylene chloride-hexane

来源与证据

ORD记录
ord-f1b9c8ee575c45eea6a0a0c2e1b6e831
来源数据集
uspto-grants-2006_10
专利号
US07129245B2

关联笔记

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