氨 → HCID 66911322，化合物

HRID 128176

反应方程式

HRID 128176 反应方程式
N.[Na].[C:3](#[N:5])[CH3:4].[Cl:6][C:7]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:8]=1[C:9]#[N:10]>O1CCCC1.C(OCC)C>[NH2:10][C:9]([C:8]1[CH:11]=[CH:12][C:13]([Cl:15])=[CH:14][C:7]=1[Cl:6])=[CH:4][C:3]#[N:5]

参与物

7

反应物 4

HCID 222氨2 次HCID 6342乙腈HCID 810502,4-二氯苯腈HCID 5360545钠2 次

产物 1

HCID 66911322HCID 66911322，化合物

试剂、催化剂与溶剂 2

HCID 3283乙醚溶剂HCID 8028四氢呋喃溶剂

实验过程

A 150 ml. portion of ammonia is condensed in a reaction flask and a small piece of sodium is added. The blue color is discharged by the addition of ferric chloride and 3.22 g. of sodium are added. After the color is discharged, 5.75 ml. of acetonitrile in 10 ml. of diethyl ether are added. The reaction is cooled in a dry ice-acetone bath and 16.6 g. of 2,4-dichlorobenzonitrile in 25 ml. of tetrahydrofuran are added dropwise. The ammonia is allowed to evaporate, the solvent is blown off with nitrogen and water is added. The mixture is extracted with methylene chloride. The organic extracts are dried over sodium sulfate and filtered through Magnesol®. The filtrate is evaporated with the addition of hexanes giving β-amino-2,4-dichlorocinnamonitrile as a white crystalline solid.

后处理

  1. customcondensed in a reaction flask
  2. temperatureThe reaction is cooled in a dry ice-acetone bath
  3. customto evaporate
  4. additionis added
  5. extractionThe mixture is extracted with methylene chloride
  6. dry with materialThe organic extracts are dried over sodium sulfate
  7. filtrationfiltered through Magnesol®
  8. customThe filtrate is evaporated with the addition of hexanes

来源与证据

ORD记录
ord-dd048b94224743e08eb1b84638c779d4
来源数据集
uspto-grants-1981_03
专利号
US04259256

关联笔记

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