氯乙酰氯 → 3,4-噻吩二羧酸

HRID 128352

反应方程式

HRID 128352 反应方程式
ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1

参与物

3

反应物 2

HCID 6577氯乙酰氯HCID 3156083,4-噻吩二羧酸酐

产物 1

HCID 2558533,4-噻吩二羧酸

实验过程

A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.

后处理

  1. temperatureat reflux for 5.5 hours
  2. distillationExcess chloroacetyl chloride is distilled under reduced pressure
  3. additionThe residue is poured into 100 ml
  4. customof water and the resulting crystals are collected
  5. customto yield 16.1 g

来源与证据

ORD记录
ord-cdd40e584b9e4651ba74e24770d441ee
来源数据集
uspto-grants-1981_03
专利号
US04259476

关联笔记

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