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海萝胶 → 7-(4-Acetyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 海萝胶 | HCID 313 | — |
| 反应物 | 乙酐 | HCID 7918 | — |
| 反应物 | 7-(1-Piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14651166 | — |
| 溶剂 | 二甲基对苯二胺二盐酸 | HCID 14798 | — |
| 产物 | 7-(4-Acetyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14651192 | — |
反应步骤
To a solution of 7-(1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (40 mg) in 5% sodium hydroxide (2 ml) is added acetic anhydride (0.1 ml) at room temperature. After the mixture is made acidic with dilute hydrochloric acid, the resultant is extracted with dichloromethane and the extract is dried over magnesium sulfate. After concentrating, the obtained residue is recrystallized from ethanol to give 7-(4-acetyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (29 mg), as white powder, m.p. 261°-263° C.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05723648 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-a4f5c585a2f143a1af864ac4739e3c74 |
| 来源说明 | uspto-grants-1998_03 |