海萝胶 → 2,2,2-trifluoro-1,1-bis(1H-pyrrol-2-yl)ethane

HRID 1305

反应方程式

HRID 1305 反应方程式
N1C=CC=C1.COC(O)[C:9]([F:12])([F:11])[F:10].Cl.[CH:15]1[CH:19]=[C:18]([CH2:20][C:21]2[NH:25][CH:24]=[CH:23][CH:22]=2)[NH:17][CH:16]=1>O1CCCC1>[NH:25]1[CH:24]=[CH:23][CH:22]=[C:21]1[CH:20]([C:18]1[NH:17][CH:16]=[CH:15][CH:19]=1)[C:9]([F:12])([F:11])[F:10]

参与物

6

反应物 4

HCID 313海萝胶HCID 8027吡咯HCID 9892三氟乙醛缩甲基半醇HCID 1408142,2'-二吡咯基甲烷

产物 1

HCID 98157622,2,2-trifluoro-1,1-bis(1H-pyrrol-2-yl)ethane收率 80%

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

Pyrrole (150 mmol) and trifluoroacetaldehyde methyl hemiacetal (75 mmol) in tetrahydrofuran are heated at reflux with catalytic amounts of hydrochloric acid for 2 hours under an inert atmosphere. GC analysis of the reaction mixture indicated the presence of the desired dipyrromethane in greater than 80% yield. Neutralization of the acid followed by work up and chromatography gave the pure bis(pyrrol-2-yl)trifluoromethylmethane 3 (R3 =CF3)). MS: m/z=214. This preparation has been disclosed in Wijesekera U.S. patent application Ser. No. 08/143,261 filed on Oct. 26, 1993.

来源与证据

ORD记录
ord-96051f14cb3b4b208319a04c297eb60a
来源数据集
uspto-grants-1998_03
专利号
US05723677

关联笔记

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