硫光气 → 3-Phenoxyphenylisothiocyanate

HRID 13530

反应方程式

HRID 13530 反应方程式
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参与物

5

反应物 3

HCID 10040硫光气HCID 771353-苯氧基苯胺HCID 21226206Ethyl acetate hexane

产物 1

HCID 220412813-Phenoxyphenylisothiocyanate

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.

后处理

  1. customthe resulting reaction
  2. temperaturemaintained for 30 min
  3. concentrationThe reaction was concentrated
  4. customazeotroped with toluene
  5. customtaken on without further purification

来源与证据

ORD记录
ord-b272333b6f17485f927833b273755ad7
来源数据集
uspto-grants-2010_06
专利号
US07728010B2

关联笔记

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