2-萘甲酸 → 1,2,3,4-四氢-2-萘甲酸

HRID 1413

反应方程式

HRID 1413 反应方程式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([OH:13])=[O:12].[Na].C(OCCOCC)C>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=[O:12]

参与物

4

反应物 3

HCID 71232-萘甲酸HCID 12375乙二醇二乙醚HCID 5360545钠

产物 1

HCID 1013701,2,3,4-四氢-2-萘甲酸

实验过程

The thus obtained 6-[4'-alkoxy-4-biphenyl)ethyl]-2-naphthalenecarboxylic acid (22) is hydrogenated in the presence of metal sodium in a solvent such as 1,2-diethoxyethane to obtain 6-[4'-alkoxy-4-biphenyl)ethyl]-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid (23). Finally, the resulting 6-[4'-alkoxy-4-biphenyl)ethyl]-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid (23) is reacted with an alcohol (24) having an asymmetric carbon in the presence of 4-N,N-dimethylaminoprydine, whereby the above-mentioned carboxylate compound (25) represented by the formula (II), in which x is --CH2CH2 --, may be obtained.

来源与证据

ORD记录
ord-bf36940ac45c47b1a49e30e635325cb5
来源数据集
uspto-grants-1998_03
专利号
US05725798

关联笔记

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