参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 反应物 | 三乙胺 | HCID 8471 | — |
| 反应物 | 1-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid | HCID 11089970 | — |
| 反应物 | (3S)-(+)-3-Aminopyrrolidine Dihydrochloride | HCID 13500644 | — |
| 溶剂 | 乙醇 | HCID 702 | — |
| 产物 | 异丙醚 | HCID 7914 | — |
| 产物 | 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt | HCID 69960535 | 142% |
反应步骤
To 1,000 mg of N,N-dimethylformamide were added 220 mg of 1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 210 mg of (3S)-3-aminopyrrolidine dihydrochloride, and 400 mg of triethylamine. The solution was stirred at 90° C. for 1.5 hours. The reaction solution was allowed to cool down, combined with 10 ml of ethanol, heated at reflux for 5 minutes, and allowed to cool down. The precipitate was collected by filtration and washed with ethanol and then with diisopropyl ether to give 220 mg of the title compound.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US05910498 |
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| 来源数据集 | uspto-grants-1999_06 |
|---|
| ORD ID | ord-8325b659aecf44de9f6a0364c03a3721 |
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| 来源说明 | uspto-grants-1999_06 |
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