参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 苯胺 | HCID 6115 | — |
| 反应物 | 3-溴-2,6-二氯吡啶 | HCID 21551819 | — |
| 试剂 | 叔丁醇钠 | HCID 23676156 | — |
| 催化剂 | 1,1'-联萘-2,2'-双二苯膦 (BINAP) | HCID 634876 | — |
| 催化剂 | 三(二亚苄基丙酮)二钯 | HCID 9811564 | — |
| 溶剂 | 1,4-二氧六环 | HCID 31275 | — |
| 产物 | 2,6-dichloro-N-phenylpyridin-3-amine | HCID 71506120 | 0% |
反应步骤
BINAP (4.67 mg, 7.50 µmol) and Pd2dba3 (2.289 mg, 2.50 µmol) were dissolved in dioxane (1ml) and flushed with nitrogen. 3-bromo-2,6-dichloropyridine (0.023 g, 0.1 mmol), aniline (0.018 mL, 0.20 mmol) and sodium tert-butoxide (0.014 g, 0.15 mmol) were weight in another flask and flushed with nitrogen. The ligand- Pd mixture was subjoined and the reaction mixture was stirred at 100°C over night. Detection of the reaction was done by LC/MS. LC/MS showed the completion of the reation. the 3-bromo-2,6-dichloropyridine as well as the aniline were gone, but no desired product was detected. NMR verified the observations. The products have not been identified.
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-22901a6299a241baa726d8f567bd79ae |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
