2,4-二氯嘧啶 → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HRID 14701

反应方程式

HRID 14701 反应方程式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:15]2[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

参与物

3

反应物 2

HCID 775312,4-二氯嘧啶HCID 27343563-甲酰基苯硼酸

产物 1

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde收率 60%

实验过程

2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 610.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).

来源与证据

ORD记录
ord-e0e0050b65ba4b42a63f0cab5037d450
来源数据集
uspto-grants-2010_06
专利号
US07732444B2

关联笔记

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