D-叔亮氨醇 → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide

HRID 1480076

反应方程式

HRID 1480076 反应方程式
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C@H:17]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:18][OH:19]>>[OH:19][CH2:18][C@H:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[C:20]([CH3:23])([CH3:22])[CH3:21]

参与物

3

反应物 2

HCID 6932847D-叔亮氨醇HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

产物 1

HCID 762834445-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide

实验过程

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-3,3-dimethyl-1-butanol (CAN 112245-09-7) as starting materials and isolated (80 mg, 80%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 327.1476 (MH+).

后处理

  1. customisolated (80 mg, 80%) as colorless oil

来源与证据

ORD记录
ord-00014752e5cd4091b6963e4de7d701a2
来源数据集
uspto-grants-2016_08
专利号
US09409866B2

关联笔记

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