N-(2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)benzamide → N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

HRID 1491188

反应方程式

HRID 1491188 反应方程式
O=C(Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)c1ccccc1>CC#N.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(S(=O)(=O)O)cc1.O=S(=O)(O)OOS(=O)(=O)O.[K].[Na].[Pd]>CC1(C)OB(c2ccccc2C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)OC1(C)C

参与物

7

反应物 1

HCID 86708425N-(2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)benzamide

产物 1

HCID 101557522N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide收率 53%

试剂、催化剂与溶剂 5

HCID 2733548联硼酸频那醇酯试剂HCID 24195884对甲苯磺酸钠试剂HCID 43835029过硫酸钾试剂HCID 587591933375-31-3催化剂HCID 6342乙腈溶剂

反应条件

温度
80 °C

来源与证据

ORD记录
ord-e3883b0f41cc48df8e630425b16a969f
来源数据集
Borylation dataset from Roche

关联笔记

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