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碘化油 → 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 碘化油 | HCID 30165 | — |
| 反应物 | 乙基-4,4-二氟环己烷羧酸盐 | HCID 2779138 | — |
| 反应物 | 5-甲氧基三阿咪唑 | HCID 2801557 | — |
| 反应物 | tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate | HCID 59340981 | — |
| 反应物 | 1,1-Difluoro-4-(iodomethyl)cyclohexane | HCID 67236985 | — |
| 产物 | 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide | HCID 58024254 | — |
反应步骤
Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07732440B2 |
| 来源数据集 | uspto-grants-2010_06 |
| ORD ID | ord-3958a078b667471db485796a4948a9a2 |
| 来源说明 | uspto-grants-2010_06 |