2-氧代-5-(4-氯苯基)-1,2-二氢吡啶-3-甲腈 → 5-(4-氯苯基)吡啶-2(1H)-酮

HRID 1506

反应方程式

HRID 1506 反应方程式
C([C:3]1[C:4](=[O:16])[NH:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:8]=1)#N>OP(O)(O)=O>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:8]=[CH:3][C:4](=[O:16])[NH:5][CH:6]=2)=[CH:14][CH:13]=1

参与物

3

反应物 1

HCID 27639102-氧代-5-(4-氯苯基)-1,2-二氢吡啶-3-甲腈

产物 1

HCID 102623725-(4-氯苯基)吡啶-2(1H)-酮收率 75.6%

试剂、催化剂与溶剂 1

HCID 1004无水磷酸二氢钾溶剂

实验过程

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

后处理

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationfiltered

来源与证据

ORD记录
ord-79fe63c48e194c1993a6d88339084cf5
来源数据集
uspto-grants-1998_03
专利号
US05726162

关联笔记

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