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甲苯 → 3-(4-Chlorocinnamoyl)-propionic acid
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 甲苯 | HCID 1140 | — |
| 反应物 | 4-氯苯甲醛 | HCID 7726 | — |
| 反应物 | 六氢吡啶 | HCID 8082 | — |
| 反应物 | 乙酰丙酸 | HCID 11579 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 产物 | 3-(4-Chlorocinnamoyl)-propionic acid | HCID 54351013 | 44% |
反应步骤
To a dry 250 ml flask equipped with a magnetic stirrer, Dean-Stark trap, and reflux condenser was charged 15 g of 4-chlorobenzaldehyde, 12.4 g levulenic acid, 5.7 ml of piperidine, and 100 ml of toluene. The reaction was refluxed for 3 hours, after which no water was observed to azeotrope from the solution. The reaction was cooled and stripped to yield a reddish-brown liquid which was triturated with hexane to yield 11.2 g of product as a yellow solid.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05726162 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-0e26495fba2b4cde9bc3510578dfcbbf |
| 来源说明 | uspto-grants-1998_03 |