醋酸 → 6-(4-氯苯基)-2H-哒嗪-3-酮

HRID 1565

反应方程式

HRID 1565 反应方程式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O)(=O)C.BrBr>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1

参与物

5

反应物 3

HCID 176醋酸HCID 24408Government regulationHCID 1209902,3,4,5-四氢-6(4-氯苯基)-3(2H-)-吡嗪酮

产物 1

HCID 6890856-(4-氯苯基)-2H-哒嗪-3-酮收率 93.1%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

后处理

  1. temperaturethe mixture was heated at 60°-70° C. for 3 h
  2. temperatureThe resulting mixture was cooled
  3. filtrationThe resulting white solid was filtered
  4. customdried

来源与证据

ORD记录
ord-a01b2f9c7fd648488efd533de927a930
来源数据集
uspto-grants-1998_03
专利号
US05726176

关联笔记

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