参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 苯胺 | HCID 6115 | — |
| 反应物 | 2,6-二氯-3-碘吡啶 | HCID 2736002 | — |
| 试剂 | 碳酸钾 | HCID 11430 | — |
| 催化剂 | 2-(二环己基膦基)联苯 | HCID 2734216 | — |
| 催化剂 | 醋酸钯 | HCID 4144353 | — |
| 溶剂 | 1,4-二氧六环 | HCID 31275 | — |
| 产物 | 2,6-dichloro-N-phenylpyridin-3-amine | HCID 71506120 | 0% |
反应步骤
Biphenyl-2-yldicyclohexylphosphine (2.80 mg, 8.00 µmol) and diacetoxypalladium (0.898 mg, 4.00 µmol) were dilutet in dioxane (1 ml) and flushed with nitrogen. 2,6-dichloro-3-iodopyridine (0.027 g, 0.1 mmol), aniline (10.96 µl, 0.12 mmol) and potassium carbonate (0.276 g, 2.00 mmol) were weight in another flask and flushed with nitrogen. The ligand-Pd mixture was subjoined and the reaction mixture was stirred at 120°C over night. The reaction was monitored by LC/MS and TLC. No desired product could be obtained and the starting material was left.
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-fc9c1fb745cd41db91cc01d3444dd381 |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
