2-庚醇 → 2-Heptyl butyrate

HRID 1604136

反应方程式

HRID 1604136 反应方程式
[CH3:1][CH:2]([OH:8])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]>C(OC(=O)CCC)(=O)CCC>[C:2]([O:8][CH:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])(=[O:8])[CH2:3][CH2:4][CH3:5]

参与物

3

反应物 1

HCID 109762-庚醇

产物 1

HCID 5294962-Heptyl butyrate收率 85%

试剂、催化剂与溶剂 1

HCID 7798丁酸酐溶剂

实验过程

Butyric anhydride (260 ml, Aldrich) was added to 2-heptanol (162 g, 1.4 mol, Aldrich) over a 1.5 hour period at 100-140° C. The mixture was heated to 160° for 4 hours. The reaction mixture was then cooled, washed with hot water, washed with aqueous sodium carbonate to remove butyric anhydride, dried over sodium sulfate, and then concentrated. Fractional distillation of the crude residue under vacuum provided 1-methylhexyl butyrate (85-110°/78-80 mm Hg, 85% yield), the structure of which was confirmed by mass spectroscopy, nuclear magnetic resonance spectroscopy, and infra red spectroscopy (not shown).

后处理

  1. temperatureThe mixture was heated to 160° for 4 hours
  2. temperatureThe reaction mixture was then cooled
  3. washwashed with hot water
  4. washwashed with aqueous sodium carbonate
  5. customto remove butyric anhydride
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated
  8. distillationFractional distillation of the crude residue under vacuum

来源与证据

ORD记录
ord-4635c16b95d14734bc4f70c31d9877c9
来源数据集
uspto-grants-1999_11
专利号
US05993879

关联笔记

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