N-苯甲酰基-L-精氨酸 → L-瓜氨酸

HRID 1676880

反应方程式

HRID 1676880 反应方程式
CN(C1C2C[C@@H]3C(C(=O)C=2C(O)=CC=1)=C(O)[C@@]1(O)[C@H]([C@H](N(C)C)C(O)=C(C(N)=O)C1=[O:18])C3)C.C[C@]1(O)[C@@H]2C(=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3C2)C(=O)C2C(O)=CC=C(Cl)C1=2.C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)[C@H](O[C@@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2NC)[C@@]1(O)C=O.CC[O:109][C:110]([C@@H:112]([NH:120]C(C1C=CC=CC=1)=O)[CH2:113][CH2:114][CH2:115][N:116]=[C:117](N)[NH2:118])=[O:111]>>[NH2:120][C@H:112]([C:110]([OH:109])=[O:111])[CH2:113][CH2:114][CH2:115][NH:116][C:117]([NH2:118])=[O:18]

参与物

5

反应物 4

HCID 123880N-苯甲酰基-L-精氨酸HCID 178482881HCID 178482881，化合物HCID 178484163HCID 178484163，化合物HCID 178484872HCID 178484872，化合物

产物 1

HCID 9750L-瓜氨酸

实验过程

Inhibition constants were determined for minocycline, chlortetracycline, and streptomycin using standard kinetic analyses. Briefly, the compounds were incubated in Reaction Buffer containing various concentrations of BAEE (0-20 mM) for 10 minutes at 37° C. PAD4 (0.2 μM) was then added to initiate the reaction and allowed to proceed for 6 additional minutes. Reactions were then quenched by flash freezing in liquid N2 and the amount of Cit produced was quantified. The data obtained for streptomycin, minocycline and chlortetracycline were fit to equations 2 and 3,

后处理

  1. additionPAD4 (0.2 μM) was then added
  2. customthe reaction
  3. customReactions were then quenched by flash

来源与证据

ORD记录
ord-3a2d3b4530144744a84496a8d9c05e64
来源数据集
uspto-grants-2011_08
专利号
US08007996B2

关联笔记

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