异氰酸苯酯 → 1-Ethyl-3-(phenylcarbamoyl)urea

HRID 1702989

反应方程式

HRID 1702989 反应方程式
[CH2:1]([NH:3][C:4]([NH2:6])=[O:5])[CH3:2].[C:7]1([N:13]=[C:14]=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O1CCOCC1>[CH2:1]([NH:3][C:4]([NH:6][C:14]([NH:13][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:15])=[O:5])[CH3:2]

参与物

4

反应物 2

HCID 7672异氰酸苯酯HCID 12254N-乙基脲

产物 1

HCID 128764091-Ethyl-3-(phenylcarbamoyl)urea收率 55.5%

试剂、催化剂与溶剂 1

HCID 312751,4-二氧六环溶剂

实验过程

In 50 ml of anhydrous dioxane, 3.5 g (0.04 mol) of ethyl urea was dissolved, and under stirring 4.8 g (0.04 mol) of phenylisocyanate was added thereinto. The reaction was carried out at a room temperature for 15 hours, then the solvent was removed by distillation under a reduced pressure. The residue thus obtained was recrystallized from ethanol-water to obtain 4.6 g (yield 55%) of 1-ethyl-5-phenylbiuret having a melting point of 80°-81.5° C.

后处理

  1. additionwas added
  2. customthe solvent was removed by distillation under a reduced pressure
  3. customThe residue thus obtained
  4. customwas recrystallized from ethanol-water

来源与证据

ORD记录
ord-ffe3594c341841a7893036c7a64812c3
来源数据集
uspto-grants-1982_09
专利号
US04350700

关联笔记

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