2-硝基-5-(三氟甲氧基)苯甲酸 → 2-氨基-5-(三氟甲氧基)苯甲酸

HRID 1717457

反应方程式

HRID 1717457 反应方程式
[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:15])([F:16])[F:17])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参与物

4

反应物 1

HCID 219046132-硝基-5-(三氟甲氧基)苯甲酸

产物 1

HCID 110853492-氨基-5-(三氟甲氧基)苯甲酸收率 98%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 702乙醇溶剂

实验过程

To a solution of 2-nitro-5-trifluoromethoxybenzoic acid (56.8 g, 0.23 mol; see step (i) above) in EtOH (1000 mL) was added 10% Pd/C (5.7 g). The resulting solution was flushed with H2 for 5 h, filtered through Celite® and concentrated in vacuo to give the crude sub-title compound (49.7 g, 98%) as a solid that was used in the next step without further purification.

后处理

  1. customThe resulting solution was flushed with H2 for 5 h
  2. filtrationfiltered through Celite®
  3. concentrationconcentrated in vacuo

来源与证据

ORD记录
ord-119c922b6c4a4fcdb1adef22e767e7a2
来源数据集
uspto-grants-2010_09
专利号
US07803954B2

关联笔记

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