乙醇 → 2-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine

HRID 1735978

反应方程式

HRID 1735978 反应方程式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:12][N:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(O)C.C(Cl)(Cl)Cl.[BH4-].[Na+]>O>[OH:3][CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:12][N:11]=2)=[CH:8][CH:9]=1)[CH3:2]

参与物

6

反应物 4

HCID 702乙醇HCID 6212三氯甲烷HCID 4311764硼氢化钠HCID 196949012-(4-Acetylphenyl)-5-decyloxypyrimidine

产物 1

HCID 214682802-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine收率 100.4%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

35.5 g (0.1 mol) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, 300 ml of ethanol and 300 ml of chloroform were supplied into a four-necked flask equipped with a stirrer and a thermometer. Then 2.8 g (0.075 mol) of sodium borohydride was added at 30°-40° C. and the mixture was stirred at the same temperature for 4 hours. The resulting reaction mixture was poured into 500 ml of water, followed by extraction and liquid separation, and the obtained chloroform layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 35.8 g of 2-(4-(1-hydroxyethyl)phenyl)-5-decyloxypyrimidine (II-c-11) (yield: 100%).

后处理

  1. customequipped with a stirrer
  2. customThe resulting reaction mixture
  3. extractionfollowed by extraction and liquid separation
  4. washthe obtained chloroform layer was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

来源与证据

ORD记录
ord-d10c3a12cbc74bec98f63f34c48781b5
来源数据集
uspto-grants-1996_07
专利号
US05539115

关联笔记

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