聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 6-Fluoro-4-(2-(4-tert-butylphenyl)ethoxy)quinazoline

HRID 1751887

反应方程式

HRID 1751887 反应方程式
[F-:1].[K+].C1N2CCOCCOCCN(CCOCCOCC2)CCOCCOC1.[N+]([C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[N:38]=[CH:37][N:36]=[C:35]2[O:42][CH2:43][CH2:44][C:45]1[CH:50]=[CH:49][C:48]([C:51]([CH3:54])([CH3:53])[CH3:52])=[CH:47][CH:46]=1)([O-])=O.O>C1COCC1>[F:1][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[N:38]=[CH:37][N:36]=[C:35]2[O:42][CH2:43][CH2:44][C:45]1[CH:50]=[CH:49][C:48]([C:51]([CH3:54])([CH3:53])[CH3:52])=[CH:47][CH:46]=1

参与物

6

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 728014,7,13,16,21,24-六氧-1,10-二氮双环[8.8.8]二十六烷HCID 522689氟化钾HCID 596786596-Nitro-4-(2-(4-tert-butylphenyl)ethoxy)quinazoline

产物 1

HCID 596786656-Fluoro-4-(2-(4-tert-butylphenyl)ethoxy)quinazoline

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

To a 25 ml round bottom flask is added potassium fluoride (82.6 mg, 1.42 mmol) and kryptofix 222 (0.53 g, 1.42 mmol). The above mixture is stirred in THF for 20 minutes after which 6-Nitro-4-(2-(4-tert-butylphenyl)ethoxy)quinazoline (0.1 g, 0.284 mmol) is added to it. The solution is refluxed for 30 minutes after which it is cooled and water is added to it. It is then extracted in dichloromethane, washed with water and dried. Purification by flash chromatography (silica gel; ethyl acetate/hexanes) gives the above compound.

后处理

  1. additionis added to it
  2. temperatureThe solution is refluxed for 30 minutes after which it
  3. temperatureis cooled
  4. extractionIt is then extracted in dichloromethane
  5. washwashed with water
  6. customdried
  7. customPurification by flash chromatography (silica gel; ethyl acetate/hexanes)
  8. customgives the above compound

来源与证据

ORD记录
ord-280ed8f1df244515957cbfa95d39d1fd
来源数据集
uspto-grants-2015_10
专利号
US09161997B2

关联笔记

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