乙二醛 → 6-硝基喹喔啉

HRID 1772004

反应方程式

HRID 1772004 反应方程式
[N+:1]([C:4]1[CH:5]=[C:6]([NH2:11])[C:7]([NH2:10])=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH:12](=O)[CH:13]=O>CCO>[N+:1]([C:4]1[CH:5]=[C:6]2[C:7](=[CH:8][CH:9]=1)[N:10]=[CH:13][CH:12]=[N:11]2)([O-:3])=[O:2]

参与物

4

反应物 2

HCID 7860乙二醛HCID 51117914-硝基邻苯二胺

产物 1

HCID 960296-硝基喹喔啉收率 97.1%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

A suspension of 4-nitrobenzene-1,2-diamine (15.3 g, 0.1 mol) and oxalaldehyde (40% in water, 17.4 g, 0.12 mol) in EtOH (150 mL) was stirred at reflux for 16 h. The mixture was then filtered, and the solid was collected to give 6-nitroquinoxaline as a yellow solid (17.0 g, yield 97%). ESI MS: m/z 176.0 [M+H]+.

后处理

  1. temperatureat reflux for 16 h
  2. filtrationThe mixture was then filtered
  3. customthe solid was collected

来源与证据

ORD记录
ord-cc9071194f8f47d59f94dee23856f614
来源数据集
uspto-grants-2016_02
专利号
US09249162B2

关联笔记

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