乙酐 → 4-甲基-2-乙酰氨基-5-硝基吡啶

HRID 1828540

反应方程式

HRID 1828540 反应方程式
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

参与物

4

反应物 2

HCID 7918乙酐HCID 2431652-氨基-4-甲基-5-硝基吡啶

产物 1

HCID 135670134-甲基-2-乙酰氨基-5-硝基吡啶

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
130 °C

实验过程

4-Methyl-5-nitro-2-pyridinamine (3.69 g, 2.41 mmol) was added with acetic anhydride (10 ml) and stirred at 130° C. for 1.5 hours. The reaction mixture was left stand for cooling, and then added with distilled water (5.4 ml) at 0° C., heated to 130° C., and stirred for 45 minutes. The reaction mixture was left stand for cooling and concentrated, and the deposited crystals were collected by filtration and washed with distilled water to obtain the title compound (4.71 g, quantitative).

后处理

  1. waitThe reaction mixture was left stand
  2. temperaturefor cooling
  3. temperatureheated to 130° C.
  4. stirringstirred for 45 minutes
  5. waitThe reaction mixture was left stand
  6. temperaturefor cooling
  7. concentrationconcentrated
  8. filtrationthe deposited crystals were collected by filtration
  9. washwashed with distilled water

来源与证据

ORD记录
ord-ae1dc800dc2640f1a468cc2b45daad5f
来源数据集
uspto-grants-2006_06
专利号
US07056917B2

关联笔记

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