N,N-二异丙基乙胺 → N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

HRID 1846490

反应方程式

HRID 1846490 反应方程式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[CH:4][C:3]=1[Cl:12].CCN(C(C)C)C(C)C.[O:22]1[CH2:26][CH2:25][CH:24]([C:27](Cl)=[O:28])[CH2:23]1>C(Cl)Cl>[Cl:12][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH:1][C:27]([CH:24]1[CH2:25][CH2:26][O:22][CH2:23]1)=[O:28]

参与物

5

反应物 3

HCID 81531N,N-二异丙基乙胺HCID 14020412四氢呋喃-3-甲酰氯2 次HCID 669783384-Amino-3-chloro-5-nitrophenol

产物 1

HCID 66978219N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂2 次

实验过程

0.40 g (2.12 mmol) 4-amino-3-chloro-5-nitrophenol were placed in 5 mL DCM. 0.44 mL DIPEA and 0.34 g tetrahydrofuran-3-carbonyl chloride were added and the mixture was stirred for 2 h at RT. A further 0.34 g tetrahydrofuran-3-carbonyl chloride was added and the mixture was stirred overnight at RT. The reaction mixture was diluted with DCM and washed with water. The organic phase was evaporated down i.vac.

后处理

  1. stirringthe mixture was stirred overnight at RT
  2. washwashed with water
  3. customThe organic phase was evaporated down i.vac

来源与证据

ORD记录
ord-750612a2b2be49fea853381032bdd2ab
来源数据集
uspto-grants-2015_02
专利号
US08952014B2

关联笔记

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