乙酰氯 → N-(3-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 1874515

反应方程式

HRID 1874515 反应方程式
[NH2:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[C:6]([O:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[C:23]([CH3:27])[CH:22]=3)=[O:20])[CH:15]=[CH:16][CH:17]=1)[N:5]=2.[C:28](Cl)(=[O:30])[CH3:29]>CN(C)C(=O)C>[C:28]([NH:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[C:6]([O:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[C:23]([CH3:27])[CH:22]=3)=[O:20])[CH:15]=[CH:16][CH:17]=1)[N:5]=2)(=[O:30])[CH3:29]

参与物

4

反应物 2

HCID 6367乙酰氯HCID 57749158N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

产物 1

HCID 57749323N-(3-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide收率 57%

试剂、催化剂与溶剂 1

HCID 31374N,N-二甲基乙酰胺溶剂

实验过程

In the same manner as in Example 28-2 and using N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (199 mg, 0.523 mmol), N,N-dimethylacetamide (2 mL) and acetyl chloride (89.2 μL, 1.26 mmol) as starting materials, the title compound (125 mg, 57%) was obtained as a white solid.

来源与证据

ORD记录
ord-c1ad646c09b542f2a4f9fbfa68bd4324
来源数据集
uspto-grants-2012_11
专利号
US08304557B2

关联笔记

加载中…