5-(4-Chloro-2-methylphenyl)-2-methyl-3-furaldehyde → [5-(4-Chloro-2-methylphenyl)-2-methyl-3-furyl] (cyclohexyl)methanol

HRID 1876983

反应方程式

HRID 1876983 反应方程式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]=[O:15])[CH:9]=2)=[C:4]([CH3:16])[CH:3]=1>C1([Mg]Br)CCCCC1.O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)[OH:15])[CH:9]=2)=[C:4]([CH3:16])[CH:3]=1

参与物

3

反应物 1

HCID 866463685-(4-Chloro-2-methylphenyl)-2-methyl-3-furaldehyde

产物 1

HCID 68514219[5-(4-Chloro-2-methylphenyl)-2-methyl-3-furyl] (cyclohexyl)methanol收率 156.4%

试剂、催化剂与溶剂 1

HCID 178420632HCID 178420632，化合物溶剂

实验过程

An operation similar to that in Example 3 (2) was performed using 5-(4-chloro-2-methylphenyl)-2-methyl-3-furaldehyde (1.6 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (10 mL) to give the title compound (1.7 g, 77%) as a white crystal.

来源与证据

ORD记录
ord-190b2a545df64902b5ffe700b3d0a12f
来源数据集
uspto-grants-2012_11
专利号
US08309580B2

关联笔记

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